The role of functional TRP ion channels on esophageal perception

功能性 TRP 离子通道对食管感知的作用

• 批准号: 21590791
• 负责人: KAMIYA Takeshi
• 金额: $ 2.91万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590791/
• 关键词: 食道; 知覚; イオンチャンネル; 食道知覚; TRP

TRPV4 channels were mainly expressed in the esophageal epithelial cells of the basal and intermediate layers. Both 4α-PDD, a selective agonist for TRPV4, and hypoosmolar solution elevated the intracellular calcium concentration in a subset of the isolated esophageal cells. These calcium increases were inhibited by RuR, a TRPV4 antagonist, and were suppressed by extracellular protons. Direct exposure of TRPV4-expressing cells to gastric acid, as would occur in the case of GERD, could influence their cellular functions, possibly aggravating the disease state.

TRPV4通道主要表达于食管基底和中间层上皮细胞。4α-PDD （TRPV4的选择性激动剂）和低盐溶液均可提高部分离体食管细胞的细胞内钙浓度。这些钙的增加被TRPV4拮抗剂RuR抑制，并被细胞外质子抑制。表达trpv4的细胞直接暴露于胃酸中，如发生GERD时，可能影响其细胞功能，可能加重疾病状态。

项目成果

Functional TRPV4 channels are expressed in mouse esophageal epithelial cells

功能性 TRPV4 通道在小鼠食管上皮细胞中表达

• 发表时间: 2011
• 作者: 塩原紀久子;他;河田浩,細井昌子,柴田舞欧,有村達之,富岡光直,船越(牧野)聖子,安野広三,山城康嗣,久保千春,須藤信行;神谷武
• 通讯作者: 神谷武

FDに知覚異常は関与するか

FD 是否涉及感觉异常？

• 发表时间: 2011
• 期刊: 分子消化器病.
• 作者: 神谷武;鹿野美千子;城卓志
• 通讯作者: 城卓志

Acid inhibits TRPV4-mediated Ca^2+influx in mouse esophageal epithelial cells

酸抑制小鼠食管上皮细胞中 TRPV4 介导的 Ca^2 内流

• DOI: 10.1111/j.1365-2982.2011.01767.x
• 发表时间: 2011
• 期刊: Neurogastroenterol Motil.
• 作者: Shikano M;Ueda T;Kamiya T;Ishida Y;Yamada T;Mizushima T;Shimura T;Mizoshita T;Tanida S;Kataoka H;Shimada S;Ugawa S;Joh T
• 通讯作者: Joh T

Acid-sensitive TRPV4 channel is expressed in mouse esophageal epithelial cells

酸敏感TRPV4通道在小鼠食管上皮细胞中表达

• 发表时间: 2011
• 作者: 岩城理恵;細井昌子;有村達之;小幡哲嗣;首藤由江;野村幸伸;河田浩;山城康嗣;久保千春;須藤信行;神谷武
• 通讯作者: 神谷武

Acid-sensitive YRPV4 channel is expressed in mouse esophageal epithelium cells

酸敏感的 YRPV4 通道在小鼠食管上皮细胞中表达

• 发表时间: 2011
• 作者: Kamiya T;Shikano M;Hirata Y;Mizushima T;Murakami K;Shimura T;Mizoshita T;Mori Y;Tanida S;Kataoka H;Ueda T;Ugasa S;Ishida Y;Shimada S;Joh T
• 通讯作者: Joh T