The role of functional TRP ion channels on esophageal perception

点击翻译按钮获取中文摘要

TRPV4 channels were mainly expressed in the esophageal epithelial cells of the basal and intermediate layers. Both 4α-PDD, a selective agonist for TRPV4, and hypoosmolar solution elevated the intracellular calcium concentration in a subset of the isolated esophageal cells. These calcium increases were inhibited by RuR, a TRPV4 antagonist, and were suppressed by extracellular protons. Direct exposure of TRPV4-expressing cells to gastric acid, as would occur in the case of GERD, could influence their cellular functions, possibly aggravating the disease state.