Investigation for the therapeutic monitoring methods using MEG and EEG

为了建立痴呆治疗的无创监测方法，我们研究了阿尔茨海默病（AD）的电生理标志物。我们发现AD患者表现为：1）α波的节律性减慢和降低，2）双侧半球之间的功能连接减少，3）听觉中潜伏期反应增强。这些变化有望作为功能性生物标志物用于AD的治疗监测。

In order to establish non-invasive monitoring methods for dementia therapy, we investigated electrophysiological markers for Alzheimer disease(AD). We found patients with AD show ; 1) Slowing and reduced rhythmicity in alpha wave, 2) reduced functional connectivity between bilateral hemispheres, and 3) enhanced auditory middle latency responses. These changes are expected to be useful for the therapeutic monitoring for AD as functional biomarkers.