Therapeutic approaches targeting colonic myofibroblasts-derived IL-24 in inflammatory bowel disease.

针对炎症性肠病中结肠肌成纤维细胞衍生的 IL-24 的治疗方法。

• 批准号: 21590809
• 负责人: ANDO Akira
• 金额: $ 2.91万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590809/
• 关键词: サイトカイン; 炎症性腸疾患; 粘膜免疫; IL-24; 遺伝子治療; IL-17

we demonstrated that IL-24 expression is enhanced in the inflamed mucosa of active IBD patients. Colonic SEMFs-derived IL-24 appears to play a protective role in the pathophysiology of IBD via a stimulation of STAT3 activation in cells mediating the innate immune response.

我们证明了IL-24在活动期IBD患者炎症黏膜中的表达增强。结肠来源的IL-24似乎通过刺激细胞中STAT3的激活而在IBD的病理生理学中发挥保护作用，该细胞介导了天然免疫反应。

项目成果

Expression of IL-24, an Activator of the JAK1/STAT3/SOCS3 Cascade, Is Enhanced in Inflammatory Bowel Disease

• DOI: 10.4049/jimmunol.0804169
• 发表时间: 2009-07-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Andoh, Akira;Shioya, Makoto;Fujiyama, Yoshihide
• 通讯作者: Fujiyama, Yoshihide

Development of a new immunoassay for the accurate determination of anti-infliximab antibodies in inflammatory bowel disease

• DOI: 10.1007/s00535-011-0474-y
• 发表时间: 2012-02-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Imaeda, Hirotsugu;Andoh, Akira;Fujiyama, Yoshihide
• 通讯作者: Fujiyama, Yoshihide

Accuracy of genotyping using the TaqMan PCR assay for single nucleotide polymorphisms responsible for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

使用 TaqMan PCR 检测对日本炎症性肠病患者硫嘌呤敏感性的单核苷酸多态性进行基因分型的准确性

• 发表时间: 2011
• 期刊: Exp Ther Med
• 影响因子: 2.7
• 作者: Osaki R;Imaeda H;Ban H;Aomatsu T;Bamba S;Tsujikawa T;Sasaki M;Fujiyama Y;Andoh A
• 通讯作者: Andoh A

Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis

• DOI: 10.3892/ijmm.2011.718
• 发表时间: 2011-10-01
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
• 影响因子: 5.4
• 作者: Imaeda, Hirotsugu;Andoh, Akira;Fujiyama, Yoshihide
• 通讯作者: Fujiyama, Yoshihide

Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn's disease using terminal restriction fragment length polymorphism analysis

• DOI: 10.1007/s00535-010-0368-4
• 发表时间: 2011-04-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Andoh, Akira;Imaeda, Hirotsugu;Fujiyama, Yoshihide
• 通讯作者: Fujiyama, Yoshihide