Investigation about the role of WT1 and PKR for the carcinogenesis or progression of hepatocellular carcinoma

我们研究了Wilms' tumor 1（WT1）基因和蛋白激酶R（PKR）在肝细胞癌（HCC）组织中过表达的作用。WT1在HCC中的表达与肿瘤发生、复发、肿瘤生长及预后有关。PKR由干扰素和利巴韦林诱导，这两种药物都是众所周知的抗丙型肝炎病毒（HCV）药物。PKR与HCV的相互作用可能与HCV诱导的肝癌发生有关，过表达WT1和PKR可能是HCC的治疗靶点。

We investigated about the role of Wilms' tumor 1(WT1) gene and Protein kinase R(PKR), which over-expressed in the tissue of hepatocellular carcinoma(HCC). The expression of WT1 in HCC was related with oncogenesis, recurrence, tumor growth and prognosis. The PKR was induced by interferon, as well as by ribavirin, both drugs are well known as anti-hepatitis C virus(HCV) drugs. The interaction of PKR and HCV would have some possibilities related with the hepatocarcinogenesis induced by HCV, and overexpressed WT1 and PKR might be therapeutic target of HCC.