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Mechanisms for Ca2+ absorption by pancreatic ductal epithelium : A study looking for a new strategy to prevent pancreatic stone formation.

Mechanisms for Ca2+ absorption by pancreatic ductal epithelium : A study looking for a new strategy to prevent pancreatic stone formation.
胰腺导管上皮吸收 Ca2 的机制:一项寻找预防胰腺结石形成新策略的研究。
批准号:
21590873
负责人:
ISHIGURO Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

ISHIGURO Hiroshi的其他基金

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中文摘要
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英文摘要
Pancreatic juice is an alkaline fluid that contains digestive enzymes and high concentrations of HCO3-. A little amount of CO32-in the juice binds to acinar cell-derived Ca2+, which leads to the precipitation of CaCO3. Pancreatic ductal epithelium is supposed to absorb luminal Ca2+ to prevent the formation of pancreatic stone. In the present study, we identified the membrane localization of Ca2+ transporters, measured the Ca2+-transport activities, and demonstrated the mechanisms to absorb luminal Ca2+ by pancreatic ductal epithelium.
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DOI: 10.1007/s00424-009-0731-6
发表时间: 2009-11-01
期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
影响因子: 4.5
作者: [Futakuchi, Sachiko, Ishiguro, Hiroshi, Goto, Hidemi]
通讯作者: Goto, Hidemi
DOI: 10.1085/jgp.200810122
发表时间: 2009-03
期刊: The Journal of general physiology
影响因子: --
作者: [Ishiguro H, Steward MC, Naruse S, Ko SB, Goto H, Case RM, Kondo T, Yamamoto A]
通讯作者: Yamamoto A
Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium.
胰管上皮分泌碳酸氢盐的生理学和病理生理学。
DOI: --
发表时间: 2012
期刊: Nagoya J Med Sci
影响因子: 0.9
作者: [Ishiguro H, Yamamoto A, Nakakuki M, Yi L, Ishiguro M, Yamaguchi M, Kondo S, Mochimaru Y.]
通讯作者: Mochimaru Y.
Pancreatic duct dysfunction and
胰管功能障碍和
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [真嶋浩聡, 堀江泰夫, 大西洋英, Ishiguro H]
通讯作者: Ishiguro H
16
    Dynamics of Morphological Changes of Cells and Its High-Accuracy Kinetic Model under High Temperature Related to Thermal Therapy
    • 批准号:
      16H04281
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.15万
    • 财政年份:
      2016
    • 负责人:
      ISHIGURO Hiroshi
    • 依托单位:
    Studies on semi-autonomous teleoperated androids that have humanlike presence
    • 批准号:
      25220004
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $132.45万
    • 财政年份:
      2013
    • 负责人:
      ISHIGURO Hiroshi
    • 依托单位:
    A study of molecular pathogenesis of chronic pancreatitis by using polycystic kidney rat
    • 批准号:
      24591010
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2012
    • 负责人:
      ISHIGURO Hiroshi
    • 依托单位:
    Characteristics of Cell Damage and Death under High Temperature Condition and Its Phenomenological Mathematical Model
    • 批准号:
      21360098
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.48万
    • 财政年份:
      2009
    • 负责人:
      ISHIGURO Hiroshi
    • 依托单位: