Mechanisms for Ca2+ absorption by pancreatic ductal epithelium : A study looking for a new strategy to prevent pancreatic stone formation.
Mechanisms for Ca2+ absorption by pancreatic ductal epithelium : A study looking for a new strategy to prevent pancreatic stone formation.
批准号:
21590873
负责人:
ISHIGURO Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Pancreatic juice is an alkaline fluid that contains digestive enzymes and high concentrations of HCO3-. A little amount of CO32-in the juice binds to acinar cell-derived Ca2+, which leads to the precipitation of CaCO3. Pancreatic ductal epithelium is supposed to absorb luminal Ca2+ to prevent the formation of pancreatic stone. In the present study, we identified the membrane localization of Ca2+ transporters, measured the Ca2+-transport activities, and demonstrated the mechanisms to absorb luminal Ca2+ by pancreatic ductal epithelium.
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DOI:
10.1007/s00424-009-0731-6
发表时间:
2009-11-01
期刊:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
影响因子:
4.5
作者:
[Futakuchi, Sachiko, Ishiguro, Hiroshi, Goto, Hidemi]
通讯作者:
Goto, Hidemi
DOI:
10.1085/jgp.200810122
发表时间:
2009-03
期刊:
The Journal of general physiology
影响因子:
--
作者:
[Ishiguro H, Steward MC, Naruse S, Ko SB, Goto H, Case RM, Kondo T, Yamamoto A]
通讯作者:
Yamamoto A
Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium.
胰管上皮分泌碳酸氢盐的生理学和病理生理学。
DOI:
--
发表时间:
2012
期刊:
Nagoya J Med Sci
影响因子:
0.9
作者:
[Ishiguro H, Yamamoto A, Nakakuki M, Yi L, Ishiguro M, Yamaguchi M, Kondo S, Mochimaru Y.]
通讯作者:
Mochimaru Y.
Pancreatic duct dysfunction and
胰管功能障碍和
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[真嶋浩聡, 堀江泰夫, 大西洋英, Ishiguro H]
通讯作者:
Ishiguro H
Fluid secretion from the pancreatic duct in PCK rats.
PCK 大鼠胰管的液体分泌。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yi L, Ishiguro H, Yamamoto A, Nakauki M, Furuya S, Nagao S, Wei M, Kondo T, Naruse S.]
通讯作者:
Naruse S.
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