Effects of Autologous Transplantation of Immature Erythroblasts in Patients With Critical Limb Ischemia

我们研究了一种新的细胞疗法的疗效，通过植入体外扩增的未成熟成红细胞培养的造血干细胞/前体细胞。10例伴有外周动脉疾病、Burger病或胶原性动脉炎的严重慢性肢体缺血患者参加了通过移植离体扩增的未成熟红系细胞进行的新型细胞疗法的初步临床试验。在临床试验中，大多数临床症状如静息痛和皮肤溃疡在4周内得到改善，并且在一年的随访中没有复发。在任何患者中均未观察到不良事件。

We investigated the efficacy of a novel cell therapy by implantation of ex vivo expanded immature erythroblasts cultured from hematopoietic stem/precursor cells. 10 patients with severe chronic limb ischemia accompanied by peripheral artery disease, Burger's disease or collagen arteritis were enrolled in a pilot clinical trial of the novel cell therapy by transplantation of ex-vivo expanded immature erythroid cells. In the clinical trial, most clinical symptoms such as rest pain and skin ulcers improved in 4 weeks, and did not recur in the one-year follow-up. No adverse events were observed in any of the patients.