Glucocorticoid-induced vascular endothelial dysfunction through activation of mineralcorticoid receptor

糖皮质激素通过激活盐皮质激素受体诱导血管内皮功能障碍

• 批准号: 21590955
• 负责人: AKAIKE Masashi
• 金额: $ 2.91万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590955/
• 关键词: グルココルチコイド; ミネラルコルチコイド; 血管内皮細胞; 酸化ストレス; 一酸化窒素

Hydrocortisone and methylprednisolone significantly increased glucocorticoid transcriptional activity and production of superoxide, and decreased expression and activation of endothelial nitric oxide synthase in cultured vascular endothelial cells. Thease effects were suppressed by spironolactone and eplerenone. Glucocorticoid excess enhanced oxidative stress and attenuated nitric oxide production through activation of mineralcorticoid recptor, leading to vascular endothelial dysfunction.

氢化可的松和甲基强的松龙显着增加糖皮质激素的转录活性和超氧化物的产生，并降低内皮型一氧化氮合酶的表达和激活在培养的血管内皮细胞。安体舒通和依普利酮可抑制上述作用。糖皮质激素过量通过激活盐皮质激素受体增强氧化应激和减弱一氧化氮的产生，导致血管内皮功能障碍。

项目成果

Effect of Low-dose (1mg/day) "Pitavastatin" on Left Ventricular Diastolic Function and Albuminuria in Patients with Hyperlipidemia

小剂量（1mg/天）“匹伐他汀”对高脂血症患者左心室舒张功能和蛋白尿的影响

• DOI: 10.1016/j.amjcard.2011.01.054
• 发表时间: 2011
• 期刊: Am J Cardiol
• 影响因子: 2.8
• 作者: 野間玄督;東幸仁;赤池雅史
• 通讯作者: 赤池雅史

Heparin Cofactor II Protects Against Angiotensin II-Induced Cardiac Remodeling Via Attenuation of Oxidative Stress in Mice

• DOI: 10.1161/hypertensionaha.110.152207
• 发表时间: 2010-09-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Sumitomo-Ueda, Yuka;Aihara, Ken-ichi;Matsumoto, Toshio
• 通讯作者: Matsumoto, Toshio

Heparin Cofactor II is an Independent Protective Factor against Peripheral Arterial Disease in Elderly Subjects with Cardiovascular Risk Factors

• DOI: 10.5551/jat.e695
• 发表时间: 2009-04-01
• 期刊: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
• 影响因子: 4.4
• 作者: Aihara, Ken-ichi;Azuma, Hiroyuki;Matsumoto, Toshio
• 通讯作者: Matsumoto, Toshio

Exacerbation of Angiotensin II-induced Cardiac Remodeling Through Enhancement of NADPHOxidase-TGF-βl Pathway in Heparin Cofactor II-Deficient Mice

通过增强肝素辅因子 II 缺陷小鼠的 NADPHO 氧化酶-TGF-β1 途径加剧血管紧张素 II 诱导的心脏重塑

• 发表时间: 2009
• 作者: 胡麗娜、成憲武;ほか(6人、2番目);上田由佳
• 通讯作者: 上田由佳

Endothelial Nitric Oxide Synthase-Independent Protective Action of Statin Against Angiotensin II-Induced Atrial Remodeling via Reduced Oxidant Injury

• DOI: 10.1161/hypertensionaha.109.146076
• 发表时间: 2010-04-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Yagi, Shusuke;Akaike, Masashi;Sata, Masataka
• 通讯作者: Sata, Masataka