Development of the treatment for fulminant type1 diabetes using the model mouse
Development of the treatment for fulminant type1 diabetes using the model mouse
批准号:
21591149
负责人:
HANAFUSA Toshiaki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
This study has shown that exendin-4 suppresses the onset of encephalomyocarditis virus(EMCV) induced diabetes, which is a model of fulminant type 1 diabetes. Exendin-4 markedly reducedβ cell destruction by inhibiting the infiltration of macrophages into the islets and the expression of EMCV infected macrophage derived chemical mediators, TNF-α, IL-1β and iNOS. Our study clarified that it could be an important strategy to suppress macrophage activation in the treatment of fulminant type1 diabetes.
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Fulminant type 1 diabetes as an important exception to the new diabetes criteria using HbA1c - response to the International Expert Committee
暴发性 1 型糖尿病是使用 HbA1c 的新糖尿病标准的一个重要例外 - 对国际专家委员会的回应
DOI:
--
发表时间:
2009
期刊:
Diabetologia 52
影响因子:
--
作者:
[Imagawa A, Hanafusa T]
通讯作者:
Hanafusa T
Exendin-4はEMCウイルスによる膵β細胞破壊を抑制する
Exendin-4 抑制 EMC 病毒诱导的胰腺 β 细胞破坏
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[佐野寛行, 花房俊昭, 佐野寛行, 佐野寛行, 佐野寛行]
通讯作者:
佐野寛行
DOI:
10.1007/s00125-009-1539-9
发表时间:
2009-12-01
期刊:
DIABETOLOGIA
影响因子:
8.2
作者:
[Kawabata, Y., Ikegami, H., Makino, H.]
通讯作者:
Makino, H.
DOI:
10.1016/j.imlet.2011.05.003
发表时间:
2011-09-30
期刊:
IMMUNOLOGY LETTERS
影响因子:
4.4
作者:
[Haseda, Fumitaka, Imagawa, Akihisa, Hanafusa, Toshiaki]
通讯作者:
Hanafusa, Toshiaki
Exendin-4, a glucagon-like peptide-1 receptor agonist, suppresses pancreaticβ-cell destruction induced by encephalomyocarditis virus.
Exendin-4 是一种胰高血糖素样肽-1 受体激动剂,可抑制脑心肌炎病毒诱导的胰腺β细胞破坏。
DOI:
--
发表时间:
2010
期刊:
Biochem Biophys Res Commun
影响因子:
--
作者:
[Sano H, Terasaki J, Mishiba Y, Imagawa A, Hanafusa T.]
通讯作者:
Hanafusa T.
共 16 条
Research on the pathogenesis of fulminant type 1 diabetes - investigation of quantitative and qualitative abnormalities of regulatory T cell -
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批准号:24591345
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2012
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负责人:HANAFUSA Toshiaki
-
依托单位:
Etiology of fulminant type 1 diabetes -analysis of the pancreas tissues
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批准号:19591069
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2007
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负责人:HANAFUSA Toshiaki
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依托单位:
Etiology of fulminant type 1 diabetes with reference to enteroviral infection
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批准号:16590896
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2004
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负责人:HANAFUSA Toshiaki
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依托单位:
Etiology of fulminant type 1 diabetes
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批准号:14370342
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2002
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负责人:HANAFUSA Toshiaki
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依托单位:
Elucidation of pathogenic mechanism of diabetes associated with the abnormal HNF gene
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批准号:10470230
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.08万
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财政年份:1998
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负责人:HANAFUSA Toshiaki
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依托单位:
Molecular biological study of viruses in type 1 disabetes mellitus
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批准号:04454562
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.42万
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财政年份:1992
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负责人:HANAFUSA Toshiaki
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依托单位:
Study on the Pathogenesis of Type 1 Diabetes Mellitus
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批准号:01480290
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.29万
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财政年份:1989
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负责人:HANAFUSA Toshiaki
-
依托单位:
Expression of MHC class II antigens on islet cells in the pathogenesis of Type I diabetes
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批准号:62480253
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.56万
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财政年份:1987
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负责人:HANAFUSA Toshiaki
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依托单位:
海外基金