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Study on the mechanism of longevity effect by adiponectin

Study on the mechanism of longevity effect by adiponectin
脂联素的长寿作用机制研究
批准号:
21591154
负责人:
YAMADA Kentaro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

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中文摘要
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英文摘要
Hyperadiponectinemia induced by transgenic expression of adiponectin prevented the premature death of metabolic syndrome model mice without affecting body weight or food ingestion. The longevity effect was not attributable to the suppression of malignant tumors or vascular events, or the augmentation of Sirt1. Anti-inflammatory action through the inhibition of AKT signaling may be involved in the beneficial effect of adiponectin. On the other hand, adiponectin did not prevent the premature death of Klotho mice.
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Effects of adiponectin on the life span of Klotho mice : From the generation of Klotho mice overexpressing adiponectin gene
脂联素对Klotho小鼠寿命的影响:从过表达脂联素基因的Klotho小鼠一代开始
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [S Otabe, T Hashinaga, X Yuan, T Fukutani, T Ohki, S Kakino, N Wada, Y Kurita, H Nakayama, Y Tajiri, K Yamada]
通讯作者: K Yamada
Effects of adiponectin on the life span of Klotho mice : From the generation of Klotho mice over-expressing adiponectin gene
脂联素对Klotho小鼠寿命的影响:从过表达脂联素基因的Klotho小鼠一代开始
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Otabe S, Hashinaga T, Yuan X, Fukutani T, Ohki T, Kakino S, Wada N, Kurita Y, Nakayama H, Tajiri Y, Yamada K]
通讯作者: Yamada K
Adiponectin Possesses Preventive Effect on Premature Death from the Metabolic Syndrome
脂联素对代谢综合征引起的过早死亡具有预防作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Otabe S, Hashinaga T, Yuan X, Fukutani T, Ohki T, Kakino S, Wada N, Kurita Y, Nakayama H, Tajiri Y, Shimokawa Y, Yamada K]
通讯作者: Yamada K
日本人の体質と健康寿命を延ばす食習慣
延长日本体质和健康寿命的饮食习惯
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ikegami H, 他10名, 山田研太郎]
通讯作者: 山田研太郎
Study of regeneration process after olfactory epithelial injury in aged mice
  • 批准号:
    19K18821
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
  • 资助金额:
    $2.66万
  • 财政年份:
    2019
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
Study on the effect of low estrogen to olfactory epithelial in mice
  • 批准号:
    16K20284
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.08万
  • 财政年份:
    2016
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
Development of a viral vector for gene therapy of chronic pain
  • 批准号:
    15K15572
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.25万
  • 财政年份:
    2015
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
Elucidation of mechanisms of rabies virus propagation and pathogenicity that are determined by N-glycans on the viral glycoprotein for application to the development of therapy for rabies
  • 批准号:
    26712024
  • 项目类别:
    Grant-in-Aid for Young Scientists (A)
  • 资助金额:
    $15.81万
  • 财政年份:
    2014
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
海外基金