Study on the mechanism of longevity effect by adiponectin
Study on the mechanism of longevity effect by adiponectin
批准号:
21591154
负责人:
YAMADA Kentaro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Hyperadiponectinemia induced by transgenic expression of adiponectin prevented the premature death of metabolic syndrome model mice without affecting body weight or food ingestion. The longevity effect was not attributable to the suppression of malignant tumors or vascular events, or the augmentation of Sirt1. Anti-inflammatory action through the inhibition of AKT signaling may be involved in the beneficial effect of adiponectin. On the other hand, adiponectin did not prevent the premature death of Klotho mice.
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Effects of adiponectin on the life span of Klotho mice : From the generation of Klotho mice overexpressing adiponectin gene
脂联素对Klotho小鼠寿命的影响:从过表达脂联素基因的Klotho小鼠一代开始
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[S Otabe, T Hashinaga, X Yuan, T Fukutani, T Ohki, S Kakino, N Wada, Y Kurita, H Nakayama, Y Tajiri, K Yamada]
通讯作者:
K Yamada
Effects of adiponectin on the life span of Klotho mice : From the generation of Klotho mice over-expressing adiponectin gene
脂联素对Klotho小鼠寿命的影响:从过表达脂联素基因的Klotho小鼠一代开始
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Otabe S, Hashinaga T, Yuan X, Fukutani T, Ohki T, Kakino S, Wada N, Kurita Y, Nakayama H, Tajiri Y, Yamada K]
通讯作者:
Yamada K
Adiponectin Possesses Preventive Effect on Premature Death from the Metabolic Syndrome
脂联素对代谢综合征引起的过早死亡具有预防作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Otabe S, Hashinaga T, Yuan X, Fukutani T, Ohki T, Kakino S, Wada N, Kurita Y, Nakayama H, Tajiri Y, Shimokawa Y, Yamada K]
通讯作者:
Yamada K
日本人の体質と健康寿命を延ばす食習慣
延长日本体质和健康寿命的饮食习惯
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ikegami H, 他10名, 山田研太郎]
通讯作者:
山田研太郎
アディポネクチンはメタボリックシンドロームによる短命化を防ぎうる-高アディポネクチン血症・KK/Taマウスの作製から-
脂联素可以预防代谢综合征引起的寿命缩短 - 从高脂联素血症 KK/Ta 小鼠的一代开始 -
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[小田邊修一, 橋永俊彦, 原暁紅, 福谷知香, 大木剛, 柿野聡美, 和田暢彦, 栗田弥生, 中山ひとみ, 田尻祐司, 下川功, 山田研太郎]
通讯作者:
山田研太郎
Study of regeneration process after olfactory epithelial injury in aged mice
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批准号:19K18821
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项目类别:Grant-in-Aid for Early-Career Scientists
-
资助金额:$2.66万
-
财政年份:2019
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负责人:YAMADA Kentaro
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依托单位:
Study on the effect of low estrogen to olfactory epithelial in mice
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批准号:16K20284
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.08万
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财政年份:2016
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负责人:YAMADA Kentaro
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依托单位:
Development of a viral vector for gene therapy of chronic pain
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批准号:15K15572
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
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财政年份:2015
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负责人:YAMADA Kentaro
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依托单位:
Elucidation of mechanisms of rabies virus propagation and pathogenicity that are determined by N-glycans on the viral glycoprotein for application to the development of therapy for rabies
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批准号:26712024
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$15.81万
-
财政年份:2014
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负责人:YAMADA Kentaro
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依托单位:
Elucidation of the relationship of indefinite complaint and malocclusion
-
批准号:24792119
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2012
-
负责人:YAMADA Kentaro
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依托单位:
Development of a rabies vaccine seed with high productivity and immunogenicity by modification of glycosylation
-
批准号:24658258
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2012
-
负责人:YAMADA Kentaro
-
依托单位:
Analysis for the molecular basis of rabies virus pathogenicity following peripheral infection
-
批准号:21780278
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2009
-
负责人:YAMADA Kentaro
-
依托单位:
Development of fatigue testing machine for columns under bending and/or torsion
-
批准号:20560441
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2008
-
负责人:YAMADA Kentaro
-
依托单位:
Traffic load monitoring under heavy load traffic and development of structural and environmental monitoring method for infrastructures
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批准号:16360228
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.66万
-
财政年份:2004
-
负责人:YAMADA Kentaro
-
依托单位:
Effects of adiponectin on metabolic syndrome : analysis of transgenic mice expressing high levels of adiponectin
-
批准号:16590897
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2004
-
负责人:YAMADA Kentaro
-
依托单位:
Studies on the STAT6 Knockout Mouse : A Novel Animal Mode for Diabetes Mellitus Associated with Visceral Obesity Syndrome
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批准号:14571114
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2002
-
负责人:YAMADA Kentaro
-
依托单位:
Measurement of Service Loading and Development of Monitoring System for Durability Evaluation of Highway Bridges due to Social and Economic Changes.
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批准号:14350241
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.03万
-
财政年份:2002
-
负责人:YAMADA Kentaro
-
依托单位:
Mechanism of Fas-mediated apoptosis of pancreatic β-cells.
-
批准号:10671085
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.64万
-
财政年份:1998
-
负责人:YAMADA Kentaro
-
依托单位:
Fatigue Design in Long Life Region under Variable Amplitude Loading
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批准号:09650525
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:1997
-
负责人:YAMADA Kentaro
-
依托单位:
Development of Fatigue Test Database with Visual Information for Welded Joints
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批准号:08555112
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$0.32万
-
财政年份:1996
-
负责人:YAMADA Kentaro
-
依托单位:
Analysis of islet antoantigens by the screening of a mouse islet cDNA expression library.
-
批准号:07671166
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.6万
-
财政年份:1995
-
负责人:YAMADA Kentaro
-
依托单位:
Development of Fatigue Check Program of Highway Bridges
-
批准号:63850102
-
项目类别:Grant-in-Aid for Developmental Scientific Research
-
资助金额:$0.96万
-
财政年份:1988
-
负责人:YAMADA Kentaro
-
依托单位:
Studies on the mechanism of islet cell destruction in type I diabetes mellitus.
-
批准号:62570514
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1987
-
负责人:YAMADA Kentaro
-
依托单位:
疲れ試験データベースの作成と疲労許容応力度の評価
-
批准号:61550327
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$0.9万
-
财政年份:1986
-
负责人:YAMADA Kentaro
-
依托单位:
海外基金