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Analysis for the molecular basis of rabies virus pathogenicity following peripheral infection

Analysis for the molecular basis of rabies virus pathogenicity following peripheral infection
外周感染后狂犬病病毒致病性的分子基础分析
批准号:
21780278
负责人:
YAMADA Kentaro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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英文摘要
It is still unclear how rabies viruses enter into the central nervous system from a bite site and then cause rabies. In this study, by serial passaging of the street rabies virus strain 1088 in a neuroblastoma cell line, we established a variant that was attenuated in mice following i. m. but not i. c. infections. We found that addition of an N-glycan to the viral G protein is related to the attenuation. Concerning the additional N-glycosylation is also found in laboratory-adapted strains but not street strains, the N-glycosylation status of the G protein is probably one of the determinants for the rabies virus pathogenicity following peripheral infection.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [山田健太郎, 野口賀津子, 西園晃]
通讯作者: 西園晃
狂犬病ウイルス街上毒のMNA細胞での連続継代による末梢感染性減弱変異株の樹立
通过在 MNA 细胞中连续传代建立狂犬病病毒街毒力外周感染性降低的突变株
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [山田健太郎、野口賀津子、松本昂, 他]
通讯作者:
Attenuation of neuroinvasiveness of street rabies virus after serial passage in mouse neuroblastoma cells
街头狂犬病病毒在小鼠神经母细胞瘤细胞中连续传代后神经侵袭性减弱
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [山田健太郎、野口賀津子、松本昂, 他, Kentaro Y., 山田健太郎]
通讯作者: 山田健太郎
Attenuation of neuroinvasive-ness of street rabies virus after serial passage in mouse neuroblastoma cells
街头狂犬病病毒在小鼠神经母细胞瘤细胞中连续传代后神经侵袭性减弱
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [山田健太郎、野口賀津子、松本昂, 他, Kentaro Y.]
通讯作者: Kentaro Y.
Study of regeneration process after olfactory epithelial injury in aged mice
  • 批准号:
    19K18821
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
  • 资助金额:
    $2.66万
  • 财政年份:
    2019
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
Study on the effect of low estrogen to olfactory epithelial in mice
  • 批准号:
    16K20284
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.08万
  • 财政年份:
    2016
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
Development of a viral vector for gene therapy of chronic pain
  • 批准号:
    15K15572
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.25万
  • 财政年份:
    2015
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
Elucidation of mechanisms of rabies virus propagation and pathogenicity that are determined by N-glycans on the viral glycoprotein for application to the development of therapy for rabies
  • 批准号:
    26712024
  • 项目类别:
    Grant-in-Aid for Young Scientists (A)
  • 资助金额:
    $15.81万
  • 财政年份:
    2014
  • 负责人:
    YAMADA Kentaro
  • 依托单位:
海外基金