Analysis for the molecular basis of rabies virus pathogenicity following peripheral infection
Analysis for the molecular basis of rabies virus pathogenicity following peripheral infection
批准号:
21780278
负责人:
YAMADA Kentaro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
It is still unclear how rabies viruses enter into the central nervous system from a bite site and then cause rabies. In this study, by serial passaging of the street rabies virus strain 1088 in a neuroblastoma cell line, we established a variant that was attenuated in mice following i. m. but not i. c. infections. We found that addition of an N-glycan to the viral G protein is related to the attenuation. Concerning the additional N-glycosylation is also found in laboratory-adapted strains but not street strains, the N-glycosylation status of the G protein is probably one of the determinants for the rabies virus pathogenicity following peripheral infection.
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狂犬病ウイルス街上毒Gタンパク質におけるN型糖鎖の追加は細胞からのウイルス粒子の放出を促進する
在狂犬病病毒街毒G蛋白中添加N-聚糖可促进病毒颗粒从细胞中释放
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[山田健太郎, 野口賀津子, 西園晃]
通讯作者:
西園晃
狂犬病ウイルス街上毒のMNA細胞での連続継代による末梢感染性減弱変異株の樹立
通过在 MNA 细胞中连续传代建立狂犬病病毒街毒力外周感染性降低的突变株
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山田健太郎、野口賀津子、松本昂, 他]
通讯作者:
他
Attenuation of neuroinvasiveness of street rabies virus after serial passage in mouse neuroblastoma cells
街头狂犬病病毒在小鼠神经母细胞瘤细胞中连续传代后神经侵袭性减弱
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山田健太郎、野口賀津子、松本昂, 他, Kentaro Y., 山田健太郎]
通讯作者:
山田健太郎
Attenuation of neuroinvasive-ness of street rabies virus after serial passage in mouse neuroblastoma cells
街头狂犬病病毒在小鼠神经母细胞瘤细胞中连续传代后神经侵袭性减弱
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山田健太郎、野口賀津子、松本昂, 他, Kentaro Y.]
通讯作者:
Kentaro Y.
A candidate for a viral element related to street rabies virus pathogenicity following peripheral infection
与外周感染后街头狂犬病病毒致病性相关的病毒元件的候选者
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kentaro Yamada, 他]
通讯作者:
他
Study of regeneration process after olfactory epithelial injury in aged mice
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Elucidation of mechanisms of rabies virus propagation and pathogenicity that are determined by N-glycans on the viral glycoprotein for application to the development of therapy for rabies
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Elucidation of the relationship of indefinite complaint and malocclusion
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Development of a rabies vaccine seed with high productivity and immunogenicity by modification of glycosylation
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Development of fatigue testing machine for columns under bending and/or torsion
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Traffic load monitoring under heavy load traffic and development of structural and environmental monitoring method for infrastructures
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Effects of adiponectin on metabolic syndrome : analysis of transgenic mice expressing high levels of adiponectin
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Studies on the STAT6 Knockout Mouse : A Novel Animal Mode for Diabetes Mellitus Associated with Visceral Obesity Syndrome
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Measurement of Service Loading and Development of Monitoring System for Durability Evaluation of Highway Bridges due to Social and Economic Changes.
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Mechanism of Fas-mediated apoptosis of pancreatic β-cells.
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Fatigue Design in Long Life Region under Variable Amplitude Loading
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Development of Fatigue Test Database with Visual Information for Welded Joints
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Analysis of islet antoantigens by the screening of a mouse islet cDNA expression library.
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Development of Fatigue Check Program of Highway Bridges
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Studies on the mechanism of islet cell destruction in type I diabetes mellitus.
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-
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海外基金