Effects of adiponectin on metabolic syndrome : analysis of transgenic mice expressing high levels of adiponectin

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To assess the effects of chronic hyperadiponectinemia on metabolic phenotypes, we established 3 lines of Transgenic mice expressing human full length adiponectin on B6 background. On high fat/high sucrose diet, the transgenic mice expressing high levels of adiponectin exhibited significantly decreased weight gain associated with less fat accumulation and smaller adipocytes in both the visceral and subcutaneous adipose tissues than wild-type B6 mice. The transgenic mice had higher rectal temperature, and greater daily oxygen consumption with a lower respiratory quotient. Moreover, high-calorie diet-induced oxidative DNA damage was significantly attenuated in the hyperadiponectinemic mice, despite unaltered food consumption. The human adiponectin transgene was transferred to KK-A^y mice by repeated back crosses. KK-A^y mice expressing human adiponectin also showed on regular chow elevated oxygen consumption rate, reduced weight gain, and improved insulin sensitivity to exogenous insulin, confirming the beneficial effects of adiponectin on obesity-related metabolic disorders.