The investigation and reconstruction of bipolar spectrum and its clinical application to depression

双相谱是连接双相I型障碍和单相抑郁症的一个概念。虽然双相I型和双相II型是精神障碍诊断和统计手册第四版（DSM-IV）的官方命名的一部分，但双相谱的概念在本手册中没有体现。为了澄清这种矛盾的情况，我们对健康志愿者和情绪障碍患者进行了研究。我们的研究结果表明，气质可以画一个双极谱和单极抑郁症之间的边界和气质可能包括几个生物因素，如光照，中枢神经系统功能，睡眠模式。虽然双相谱的概念强调连续性，但可能存在一个转折点，使药物反应发生变化，即双相谱对情绪稳定剂的反应和单相抑郁对抗抑郁药的反应。

Bipolar spectrum is a concept which bridges between bipolar I disorder and unipolar depression. Although bipolar I and bipolar II are part of the official nomenclature of Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition(DSM-IV), such concept of bipolar spectrum is not represented in this manual. To clarify this conflicting situation, we performed studies using healthy volunteers and patients with mood disorders. Our results suggest that temperaments may draw a boundary between bipolar spectrum and unipolar depression and temperaments may consist of several biological factors such as illuminance, central serotonergic function, and sleep pattern. Although the concept of bipolar spectrum emphasizes continuity, there may be an inflexion point which makes changes in drug responses, which are the response of bipolar spectrum to mood stabilizers and that of unipolar depression to antidepressants.