Longitudinal study of the relationship among psychiatric symptoms, social functioning and brain basis in individuals with an at-risk mental state(ARMS).

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To investigate the biological changes in the brain of individuals with an at-risk mental state, we compared the differences between ARMS subjects and healthy control subjects using MRI. The main findings were:Reduction of the white matter integrity in corpus callosum and cingulum of ARMS subjects compared to healthy control subjects.Volume reduction of the entorhinal cortex after a year of follow-up among ARMS subjects who developed psychosis compared to subjects those who did not.