To elucidate the immune activity of heavy ion irradiation in inhibiting lung metastasis in treatment-resistant cancer

阐明重离子照射抑制难治性癌症肺转移的免疫活性

• 批准号: 21591624
• 负责人: YAMADA Shigeru
• 金额: $ 2.91万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591624/
• 关键词: 重粒子; 転移; 難治性がん; 重粒子線; 転移抑制; Linea Energy Transfer

The cell mediated immunity mainly on the NK-cell was activated by heavy-ion particle radiation, and the suppression of metastases was induced by the activation. Heavy-ion particle radiation induced monitoring cells such as a macrophage, dendritic cells or the mast cells which had TLR(Toll like receptor) to recognize cancer cells easily, and an NK-cell was activated by increasing a production of TNF-α and IL-12 which were cytokines secreted by those cells more or IL-12 and increased a production of IFN - γ secreted more by an NK-cell, and it was shown that various cell mediated immunity mechanisms were activated, and the antitumor action for metastases was demonstrated.

重离子粒子辐射可激活以NK细胞为主的细胞免疫，并通过激活诱导抑制肿瘤转移。重离子粒子照射后，巨噬细胞、树突状细胞或肥大细胞等巨噬细胞、树突状细胞或肥大细胞等具有TLR样受体的巨噬细胞容易识别癌细胞，而NK细胞则通过增加这些细胞分泌的细胞因子肿瘤坏死因子-α和IL-12而被激活，并使NK细胞分泌的干扰素-γ增多，从而激活了多种细胞免疫机制，显示了抗肿瘤转移的作用。

项目成果

Compensatory elllargement of the liver after treatment of hepatocellular carcinoma pith carbon ion radiotherapy-Relation to prognosis and liver function

肝细胞癌髓碳离子放疗后肝脏代偿性肿大与预后及肝功能的关系

• 发表时间: 2010
• 期刊: Rad iotherapy and Oncology
• 作者: Hiroshi Imada;Hirotoshi Katou;Shigeru Yamada;et.al
• 通讯作者: et.al

局所進行膵癌に対する集学的治療の進歩-重粒子線治療の現状

局部晚期胰腺癌多学科治疗进展——重粒子线治疗现状

• 发表时间: 2012
• 作者: 山田 滋;寺嶋 広太郎;篠藤 誠;安田 茂雄
• 通讯作者: 安田 茂雄

Carbon Ion Radiotherapy for Patients with Pancreatic Cancer

胰腺癌患者的碳离子放射治疗

• 发表时间: 2012
• 作者: Suzuki K;Aoyama H(6^);et al.;Shigeru Yamada
• 通讯作者: Shigeru Yamada

Pancreas / Rectum

胰腺/直肠

• 发表时间: 2012
• 作者: Shigeru Yamada;Makoto Shinoto;Koutaro Terashima;Shigeo Yasuda;Hiroshi Imada;Tadashi Kamada;Hirohiko Tsujii;Shinichiro Mori
• 通讯作者: Shinichiro Mori

膵臓癌幹細胞様細胞における炭素線の影響

碳离子对胰腺癌干细胞样细胞的影响

• 发表时间: 2011
• 作者: 大西 和彦;崔 星;山田 滋
• 通讯作者: 山田 滋