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Clarification of new adaptive mechanism on physical exercise

阐明体育锻炼新适应机制

基本信息

批准号：
18500507
负责人：
YAMADA Shigeru
金额：
$ 2.27万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500507/
关键词：
Exercise stem cell muscle hypertrophy SP cell Notch signaling system blood cell DELTA 幹細胞 PAX7

项目摘要

Heretofore, the adaptive mechanism of the physical exercise has been caught as the entire living body or a change in the organization to the motor stimulation. Then, it paid attention to two mechanisms as an adaptive mechanism to the exercise of skeletal muscles. Those two mechanisms exist. One is the communications between the biological tissue. Another is intercellular communications. In this experiment, the supply of the stem cell was undertaken from the entire body along with the muscular hypertrophy, the mechanism deeply related to the muscular hypertrophy and the regeneration. That is, it was almost clarified that a new adaptive mechanism as the supply system of the cell existed. It was clarified that the number of mono nuclear cells increased to the 4-8th after overload by tenotomy. A lot of pluripotent stem cells and the hemopoietic progenitor cells etc. of all cell lineages are contained in these mono mono nuclear cells. Then, the maturity white blood corpuscle nature was dele … More ted, and the prosperity and decay of a remaining mono nuclear cellsl were observed. As a result, it turned out that the number of these immature cell groups decreased rapidly from blood by exercise. It is thought that a lot of blood cells permeated in the musculature for about two days after the workload by tenotomy. In addition, decrease of the cell groups except a hemopoietic stem cell and a multifunctional stem cell were rapidly shown. The SP cell and the undifferentiation stem cells are included in these cell groups. The possibility that these results also contributes to the skeletal muscle hypertrophy is thought. It was shown that the number of SP cells in blood increased along with the exercise. It was clarified that a multifunctional stem cell was mobilized by the skeletal muscle hypertrophy inducement by tenotomy. In addition, it paid attention to the Notch cell signaling system and it researched in intercellular communications. In a document research, the role of the Notch cell signaling system and the importance were shown. Moreover, it was guessed that the intercellular communication accomplished the key role to the controlling mechanism of the muscle cell growth because the muscular hypertrophy had been induced by ganma secretase inhibitor administration in the our researches though it did not show in the report. Less

到目前为止，体育锻炼的适应机制一直被捕捉为整个活体或组织对运动刺激的变化。然后，重点研究了两种机制作为骨骼肌运动的适应机制。这两种机制是存在的。其一是生物组织之间的交流。另一种是细胞间通信。在本实验中，干细胞的供应是伴随着肌肉肥大而从全身进行的，其机制与肌肉肥大和再生密切相关。也就是说，几乎澄清了作为细胞供应系统的新的适应机制的存在。肌腱切断超负荷后，单个核细胞数量增加到第4~8个。这些单个核细胞中含有大量的多能干细胞和造血祖细胞等所有细胞系。于是，成熟的白血球自然是德乐…更多的TED，以及剩余的单核细胞的繁荣和衰败被观察到。结果，通过运动，这些未成熟细胞群的数量从血液中迅速减少。据认为，肌腱切断术后两天左右，大量血细胞渗透到肌肉中。此外，除1个造血干细胞和1个多功能干细胞外，其余细胞群迅速减少。这些细胞群包括SP细胞和未分化干细胞。人们认为，这些结果也可能导致骨骼肌肥大。结果表明，随着运动强度的增加，血中SP细胞数量增加。结果表明，肌腱切断诱导骨骼肌肥大可动员多功能干细胞。此外，还关注了Notch细胞信号系统，并对细胞间通信进行了研究。在一项文献研究中，Notch细胞信号系统的作用和重要性被展示出来。此外，在我们的研究中，由于甘露糖分泌酶抑制剂诱导了肌肉肥大，推测细胞间通讯在肌肉细胞生长的调控机制中发挥了关键作用，尽管报告中没有显示这一点。较少