Genetic polymorphism of TLR CD40L in the mechanism of pathogenesis of Buerger's disease

TLR CD40L基因多态性在布尔格病发病机制中的作用

• 批准号: 21591630
• 负责人: KUDO Toshifumi
• 金额: $ 2.08万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591630/
• 关键词: 血管外科学; Buerger病; TLR; 歯周病; 遺伝的多型; Buerer病; 遺伝子多型; CD40

Myeloid differentiation primary-response protein 88(MyD88) is a key signaling adaptor for all Toll-like receptors. The frequency of GG genotype was significantly lower in the Buerger's disease patients than in the controls. The frequency of Formyl peptide receptors(FPR) 1 TCCCT haplotype was significantly higher in the Buerger's Disease patients than in the controls. The results of the current study suggest that TLR-MyD88 pathway and bacterial infection immunity play a role in the mechanism of pathogenesis of Buerger's disease as well as periodontal disease.

髓样分化初级反应蛋白88（MyD 88）是所有Toll样受体的关键信号衔接子。Buerger病组GG基因型频率显著低于对照组。甲酰肽受体（FPR）1 TCCCT单倍型的频率在Buerger病患者中显著高于对照组。本研究结果提示TLR-MyD 88通路和细菌感染免疫在Buerger病和牙周病的发病机制中起作用。

项目成果

閉塞性動脈硬化症に対する、歯周病原細菌の関連

牙周病原菌与闭塞性动脉硬化的关系

• 发表时间: 2009
• 作者: 豊福崇浩;井上芳徳;寺崎宏明;工藤敏文;地引政利;菅野範英;梅田誠;和泉雄三;須田智也;岩井武尚
• 通讯作者: 岩井武尚

Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease

• DOI: 10.1007/s00439-007-0408-1
• 发表时间: 2007-11-01
• 期刊: HUMAN GENETICS
• 影响因子: 5.3
• 作者: Chen, Zhiyong;Takahashi, Megumi;Kimura, Akinori
• 通讯作者: Kimura, Akinori

バージャー病患者の逍遥性静脈炎、表在静脈弁不全についての考察と新知見

布尔格病患者静脉炎和浅静脉瓣膜关闭不全的讨论和新发现

• 发表时间: 2011
• 期刊: 静脈学
• 作者: 岩井武尚;佐藤彰治;久米博子;井上芳〓;梅田誠;加賀山知子;広川雅之
• 通讯作者: 広川雅之

Differential detection rate of periodontopathic bacteria in atherosclerosis

动脉粥样硬化牙周病菌的鉴别检出率

• 发表时间: 2011
• 期刊: Surg Today
• 影响因子: 2.5
• 作者: Toyofuku T;Inoue Y;Kurihara N;Kudo T;Jibiki M;Sugano N;Umeda M;Izumi Y.
• 通讯作者: Izumi Y.

Association between periodontitis and anti-cardiolipin antibodies in Buerger disease

• DOI: 10.1111/j.1600-051x.2009.01467.x
• 发表时间: 2009-10-01
• 期刊: JOURNAL OF CLINICAL PERIODONTOLOGY
• 影响因子: 6.7
• 作者: Chen, Yi-Wen;Nagasawa, Toshiyuki;Izumi, Yuichi
• 通讯作者: Izumi, Yuichi