Mechanism of drug resistance by Epithelial-Mesenchymal Transition and bone marrow stem cell
Mechanism of drug resistance by Epithelial-Mesenchymal Transition and bone marrow stem cell
批准号:
21591720
负责人:
TSUTSUMI Soichi
金额:
$0.42万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The epithelial to mesenchymal transition(EMT)is a molecular process through which an epithelial cell undergoes differentiation into a mesenchymal phenotype. The relationship between EMT and resistance to an anti-cancer drug in colorectal cancer remains unknown. In this study, we investigated the acquisition of EMT by 5-FU in colorectal cell lines. 5-FU resistant cell lines did not change into a mesenchymal phenotype. This study suggests that EMT phenotype may not play a significant role in anti-cancer agent resistance in colorectal cancer
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Characterization of special propulsive contractions during rectal evacuation in a canine model of intestinal extrinsic denervation and rectal transection
肠外去神经和直肠横断犬模型直肠排空过程中特殊推进收缩的表征
DOI:
--
发表时间:
2010
期刊:
Int J Colorectal Dis
影响因子:
2.8
作者:
[Tabe Y, Mochiki E, Yanai M, Toyomasu Y, Ando H, Ohno T, Tsutsumi S, Asao T, Kuwano H]
通讯作者:
Kuwano H
Phosphoglucose isomerase enhances colorectal cancer metastasis
磷酸葡萄糖异构酶增强结直肠癌转移
DOI:
--
发表时间:
2009
期刊:
Int J Oncol 35
影响因子:
--
作者:
[Sato M, Shibata C, Kikuchi D, Ikezawa F, Imoto H, Kakyo M, Kinouchi M, Tanaka N, Miura K, Naitoh T, Ogawa H, Sasaki I, 島田英昭, Soichi Tsutsumi]
通讯作者:
Soichi Tsutsumi
DOI:
10.1016/j.ejca.2010.02.021
发表时间:
2010-07-01
期刊:
EUROPEAN JOURNAL OF CANCER
影响因子:
8.4
作者:
[Li, Jie, Hou, Ni, Kuwano, Hiroyuki]
通讯作者:
Kuwano, Hiroyuki
DOI:
10.1186/1471-2407-11-216
发表时间:
2011-06-02
期刊:
BMC cancer
影响因子:
3.8
作者:
[Fujii T, Tabe Y, Yajima R, Yamaguchi S, Tsutsumi S, Asao T, Kuwano H]
通讯作者:
Kuwano H
DOI:
--
发表时间:
2010
期刊:
Int Surg
影响因子:
0.1
作者:
[Toyomasu Y, Tsutsumi S, Yamaguchi S, Mochiki E, Asao T, Kuwano H]
通讯作者:
Kuwano H
共 20 条
Immunotherapy of carcinomatous pleuritis and peritonitis targeting phosphoglucose isomerase as a vaccine.
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批准号:16591246
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.46万
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财政年份:2004
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负责人:TSUTSUMI Soichi
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依托单位:
海外基金