Application of Serum Antibodies against Multiple Tumor Antigen to Diagnose Esophageal Squamous Cell Carcinoma

多种肿瘤抗原血清抗体在食管鳞癌诊断中的应用

• 批准号: 21591717
• 负责人: SHIMADA Hideaki
• 金额: $ 2.83万
• 依托单位: Toho University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591717/
• 关键词: SEREX; VEGF; p53; ELISA; 食道癌; 血清抗体; 腫瘍マーカー

Purpose of this study was(i) establish ELISA system to detect serum anti-VEGF antibodies, and(ii) evaluate positive rate of serum anti-VEGF antibodies in patients with esophageal squamous cell carcinoma. Using a cut-off value of mean+3SD of serum anti-VEGF antibody level of healthy controls, positive rate of patients with esophageal squamous cell carcinoma was 6.6%(6/91). No clinicopathological factors were associated with presence of anti-VEGF antibodies.

本研究的目的是（i）建立ELISA系统检测血清抗VEGF抗体，以及（ii）评估食管鳞癌患者血清抗VEGF抗体的阳性率。以健康对照者血清抗VEGF抗体水平平均值±3SD为界值，食管鳞癌患者的阳性率为6.6%（6/91）。没有临床病理因素与抗 VEGF 抗体的存在相关。

项目成果

Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma: a possible new serum marker for esophageal cancer

• DOI: 10.1007/s00535-009-0060-8
• 发表时间: 2009-07-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Shimada, Hideaki;Kagaya, Akiko;Hiwasa, Takaki
• 通讯作者: Hiwasa, Takaki

腫瘍マーカー 血清p53抗体-診断モニタリング-

肿瘤标志物血清p53抗体-诊断监测-

• 发表时间: 2010
• 期刊: 日本臨床
• 作者: 島田英昭;山崎有浩;谷島聡;大嶋陽幸;小池淳一
• 通讯作者: 小池淳一

Angiogenesis-related factors are molecular targets for diagnosis and treatment patients with esophageal carcinoma.

血管生成相关因子是食管癌诊断和治疗的分子靶点。

• 发表时间: 2010
• 期刊: Ann Thorac Cardiovasc Surg
• 作者: Oshima Y;Yajima S;Yamazaki K;Matsushita K;Tagawa M;Shimada H
• 通讯作者: Shimada H

Clinical utility of serum p53 antibody for patients with esophageal carcinoma

食管癌患者血清p53抗体的临床应用

• 发表时间: 2011
• 作者: Shimada H;Yamazaki K
• 通讯作者: Yamazaki K

Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells.

• DOI: 10.1186/1471-2121-12-41
• 发表时间: 2011-09-27
• 期刊: BMC cell biology
• 作者: Tonoike Y;Matsushita K;Tomonaga T;Katada K;Tanaka N;Shimada H;Nakatani Y;Okamoto Y;Nomura F
• 通讯作者: Nomura F