Biodegradable stent of external wrapping with autologous vein grafts prevents graft stenosis at long term in a canine model

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In the CABG surgery, autologous vein graft stenosis and occlusion at long term has been a significant clinical issue. It was said that reduction of the wall stress was very important in order to prevent graft stenosis. So, we tested the hypothesis that biodegradable stent wrapped externally can prevent graft stenosis at long term in a canine vein graft model. Femoral artery graft interposition was performed in beagles. They were divided into 3 groups : graft interposition without external stent(control); with biodegradable stent (poly L-lactic acid and epsilon-caprolactone copolymer(P(LA/CL)); with non-biodegradable stent(polypropylene). At P(LA/CL)group, diameters of vein graft was the similar value at any point, patency was significantly improved compared with the other groups. Therefore biodegradable stent of external wrapping with autologous vein grafts can prevent graft stenosis at long term in a canine model.