Biodegradable stent of external wrapping with autologous vein grafts prevents graft stenosis at long term in a canine model

自体静脉移植物外包裹的可生物降解支架在犬模型中长期预防移植物狭窄

• 批准号: 21591786
• 负责人: IGUCHI Atsushi
• 金额: $ 3万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591786/
• 关键词: 冠動脈バイパス; ステント; 生体吸収性素材; 再生医学; 冠動脈バイパス術

In the CABG surgery, autologous vein graft stenosis and occlusion at long term has been a significant clinical issue. It was said that reduction of the wall stress was very important in order to prevent graft stenosis. So, we tested the hypothesis that biodegradable stent wrapped externally can prevent graft stenosis at long term in a canine vein graft model. Femoral artery graft interposition was performed in beagles. They were divided into 3 groups : graft interposition without external stent(control); with biodegradable stent (poly L-lactic acid and epsilon-caprolactone copolymer(P(LA/CL)); with non-biodegradable stent(polypropylene). At P(LA/CL)group, diameters of vein graft was the similar value at any point, patency was significantly improved compared with the other groups. Therefore biodegradable stent of external wrapping with autologous vein grafts can prevent graft stenosis at long term in a canine model.

在冠脉搭桥手术中，自体静脉移植物的狭窄和闭塞长期存在一直是一个重要的临床问题。为了防止移植物狭窄，减少管壁应力是非常重要的。因此，我们在犬静脉移植模型中验证了生物可降解支架外包装长期防止移植物狭窄的假设。小猎犬行股动脉介入移植术。患者分为3组：移植物间置不外支架组（对照组）；采用可生物降解支架(聚l -乳酸与ε -己内酯共聚物（P(LA/CL)）；采用不可生物降解支架（聚丙烯）。在P（LA/CL）组，移植静脉在任何点的直径值相近，与其他组相比，通畅性明显提高。因此，在犬模型中，自体静脉外包装支架可以长期预防移植物狭窄。