Protective effect of rare sugar D-allose on ischemic injuries occurred by brain embolism.
Protective effect of rare sugar D-allose on ischemic injuries occurred by brain embolism.
批准号:
21591846
负责人:
TOKUDA Masaaki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We performed the experiment using a rat model with brain ischemia and reperfusion. Male SD rats weighing 350-400g were used. The ischemic model was made by placing a nylon thread in the mid brain artery for 60 min. D-allose reduces the impaired region of brain embolism in a dose dependent manner. D-allose(50mg/ kg~800mg/ kg) was administered intravenously. Oxidative stress markers were markedly reduced by D-allose. Thus, D-allose was revealed to reduce the impaired region of brain embolism in a dose-dependent manner.
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DOI:
10.1016/j.neulet.2010.10.004
发表时间:
2011-01-03
期刊:
NEUROSCIENCE LETTERS
影响因子:
2.5
作者:
[Nakamura, Takehiro, Tanaka, Shinji, Miyamoto, Osamu]
通讯作者:
Miyamoto, Osamu
How the New frontier of D-psicose world has been created in Kagawa
D-阿洛酮糖世界的新前沿是如何在香川创建的
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Matsushita N, Kitazato K, Shimada K, Kinouchi T, Kanematsu Y, Satomi J, 杉生憲志, Masaaki Tokuda]
通讯作者:
Masaaki Tokuda
希少糖の医薬品及び食品への利用
稀有糖在医药和食品中的用途
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[徳田雅明, 塚本郁子]
通讯作者:
塚本郁子
Rare sugar D-allose strongly induces Thioredoxin interacting protein (TXNIP) and inhibits osteoclast differentiation in Raw264 cells
稀有糖 D-阿洛糖强烈诱导硫氧还蛋白相互作用蛋白 (TXNIP) 并抑制 Raw264 细胞中的破骨细胞分化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Fuminori Yamaguchi, 他8名]
通讯作者:
他8名
D-allose reduces cisplatin rephrotoxicity by inhibition of tumor necrosis factor-alfa
D-阿洛糖通过抑制肿瘤坏死因子-α 降低顺铂肾毒性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yuki Miyawaki, 他4名]
通讯作者:
他4名
共 6 条
Neuron specific calcium-binding Protein, calbrain, is involved in memory formation.
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批准号:11694284
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$2.43万
-
财政年份:1999
-
负责人:TOKUDA Masaaki
-
依托单位:
Role of cyclin-dependent kinase 5 in Alzheimer's brain.
-
批准号:09044317
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$2.3万
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财政年份:1997
-
负责人:TOKUDA Masaaki
-
依托单位:
海外基金