a role of glial cells in the central nervous system to prevent retrograde degeneration of the facial nucleus and a mechanism for axonal regeneration

神经胶质细胞在中枢神经系统中防止面神经核逆行变性的作用以及轴突再生的机制

• 批准号: 21591859
• 负责人: HASEGAWA Mitsuhiro
• 金额: $ 2.91万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591859/
• 关键词: facial motoneuron; retrograde degeneration; axonal injury; brainstem; glial cell; axonal injuly; axonal regeneration; facial nerve; facial nucleus; axotomy; central nervous system; stereotactic surgery; facial nerve injury; astrocyte; Schwan

Axonal injury models throughout the facial nerve from brainstem to the target was utilized to analyze the mechanism of retrograde motoneuron degeneration and seek the preventing factors against the neuronal loss. Peripheral injury induced little motoneuron degeneration, but brainstem injury showed massive and rapid degeneration resulting in only 3% neuronal survival on day 28.Peripheral nerve autograft induced 8-times axonal survival and erythropoietin 3-times, but no other neuroprotective factors found so far. Nitric oxide was supposed to be related to the mechanism of neuronal loss but apoptosis was not. The neuroprotective mechanism for retrograde degeneration might give us the cue for CNS regeneration.

本研究利用面神经从脑干到靶区的轴索损伤模型，分析面神经运动神经元逆行性变性的机制，寻找防止面神经运动神经元变性的因素。外周神经损伤后，运动神经元变性程度较轻，脑干损伤后，运动神经元变性迅速，28d时仅有3%的神经元存活。自体外周神经移植后，轴突存活8倍，促红细胞生成素3倍，但未发现其他神经保护因子。一氧化氮被认为与神经元丢失的机制有关，而凋亡则与之无关。逆行变性的神经保护机制可能会给我们中枢神经系统再生的线索。

项目成果

A proposal for standardized analysis of the results of microvascular decompression for trigeminal neuralgia and hemifacial spasm

• DOI: 10.1007/s00701-012-1277-5
• 发表时间: 2012-05-01
• 期刊: ACTA NEUROCHIRURGICA
• 影响因子: 2.4
• 作者: Kondo, Akinori;Date, Isao;Yamakami, Iwao
• 通讯作者: Yamakami, Iwao

Ocular dominance affects magnitude of dipole moment

眼优势影响偶极矩的大小

• 发表时间: 2010
• 期刊: An MEG study Neuro Report
• 作者: H Shima;M Hasegawa;他6名
• 通讯作者: 他6名

脳神経減圧術における必須事項と無駄

脑神经减压的要点和浪费

• 发表时间: 2011
• 作者: 長谷川光広、吉田耕一郎、安達一英;ほか
• 通讯作者: ほか

脳腫瘍摘出術の現状と展望日本外科系連合学会誌

脑肿瘤切除手术的现状与展望 日本外科学会杂志

• 发表时间: 2009
• 作者: 長谷川光広、吉田耕一郎、長久伸也;ほか;Chida K;Hasegawa M;伊丹尚多;長谷川光広
• 通讯作者: 長谷川光広

Strategy for dissection of tumor capsule from the critical neural and vascular structures in meningioma surgery-clinicopathological analysis

脑膜瘤手术中从关键神经和血管结构中剥离肿瘤包膜的策略-临床病理分析

• 发表时间: 2010
• 作者: 渡辺克成;齊藤延人;好本裕平;佐々木富男;Saito H;M Hasegawa
• 通讯作者: M Hasegawa