Role of MIF on the process of fracture healing and the effect of its regulation
Role of MIF on the process of fracture healing and the effect of its regulation
批准号:
21591909
负责人:
ONODERA Shin
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We investigated the role of macrophage migration inhibitory factor (MIF) on the process of fracture healing using MIF KO mice. In MIF KO mice, the mechanical properties of the fracture callus were decreased at the early stage of fracture healing, which was caused at least in part by the delay in the calcification of osteoid or the decrease in the number of osteoclasts. These were considered to be associated with decreased mRNA expression of MMP-2, MT1-MMP, Cathepsin K, and alkaline phosphatase.
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DOI:
10.1186/1471-2474-12-49
发表时间:
2011-02-22
期刊:
BMC musculoskeletal disorders
影响因子:
2.3
作者:
[Yokota M, Yasuda K, Kitamura N, Arakaki K, Onodera S, Kurokawa T, Gong JP]
通讯作者:
Gong JP
DOI:
10.1186/1471-2474-12-213
发表时间:
2011-09-29
期刊:
BMC musculoskeletal disorders
影响因子:
2.3
作者:
[Imabuchi R, Ohmiya Y, Kwon HJ, Onodera S, Kitamura N, Kurokawa T, Gong JP, Yasuda K]
通讯作者:
Yasuda K
DOI:
10.1007/s00198-010-1385-0
发表时间:
2011-06-01
期刊:
OSTEOPOROSIS INTERNATIONAL
影响因子:
4
作者:
[Kobayashi, T., Onodera, S., Yasuda, K.]
通讯作者:
Yasuda, K.
マクロファージ遊走阻止因子遺伝子の欠損が骨折治癒に与える効果
巨噬细胞迁移抑制因子基因缺失对骨折愈合的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小林巧, 小野寺伸, 遠山晴一, 近藤英司, 安田和則]
通讯作者:
安田和則
DNA-vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models.
针对巨噬细胞迁移抑制因子的 DNA 疫苗可改善小鼠模型中的特应性皮炎。
DOI:
--
发表时间:
2009
期刊:
J Allergy Clin Immunol 124
影响因子:
--
作者:
[Hamasaka A, Abe R, Koyama Y, Yoshioka N, Fujita Y, Hoshina D, Sasaki M, Hirasawa T, Onodera S, Ohshima S, Leng L, Bucala R, Nishihira J, Shimizu T, Shimizu H.]
通讯作者:
Shimizu H.
Role of MIF in wear particle-induced oeteolysis and its regulation by MIF-DNA vaccination
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批准号:19591746
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:ONODERA Shin
-
依托单位:
The pathomechanism of postmenopausal osteoporosis-the involvement of MIF and therapeutic approach using MIF-DNA vaccine
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批准号:17591542
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2005
-
负责人:ONODERA Shin
-
依托单位:
The development of MIF vaccine and its therapeutic effect on murine arthritis model
-
批准号:15591560
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2003
-
负责人:ONODERA Shin
-
依托单位:
海外基金