Osteogenic differentiation of culture expanded bone marrow cells under tensile and compressive strains
Osteogenic differentiation of culture expanded bone marrow cells under tensile and compressive strains
批准号:
21591915
负责人:
KITOH Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Alkaline phosphatase activity within the culture media were significantly elevated in the dynamic stretch(DS) group and the dynamic compression(DC) group compared to the control group. The DC group showed significant elevated levels of mRNA expression of HIF 1α. Western blotting analysis demonstrated increased amount of HIF 1αprotein within the nucleous in the DC, DS, and static stretch(SS) groups. Favorable new bone formation was observed when the bone marrow cells cultured under the dynamic stretch condition were implanted with PRP into the distraction gap of rat bone lengthening models.
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DOI:
10.1136/jmg.2009.075358
发表时间:
2010-10-01
期刊:
JOURNAL OF MEDICAL GENETICS
影响因子:
4
作者:
[Dai, J., Kim, O-H, Ikegawa, S.]
通讯作者:
Ikegawa, S.
ペルテス病の治療成績に関連する因子の検討
Perthes病治疗结果相关因素的研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[鬼頭浩史, 金子浩史, 北小路隆彦, 服部義, 石黒直樹.]
通讯作者:
石黒直樹.
DOI:
10.1007/s00439-011-1006-9
发表时间:
2011-11-01
期刊:
HUMAN GENETICS
影响因子:
5.3
作者:
[Kaneko, Hiroshi, Kitoh, Hiroshi, Ohno, Kinji]
通讯作者:
Ohno, Kinji
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kaneko H, Kitoh H, Yamamoto R, IshiguroN, Ohno K]
通讯作者:
Ohno K
Induction of systemic bone changes by preconditioning total body irradiation for bone marrow transplantation
骨髓移植预处理全身照射诱导全身骨变化
DOI:
--
发表时间:
2009
期刊:
Pediatr Radiol 39
影响因子:
--
作者:
[Miyazaki O, Nishimura G, Okamoto R, Masaki H, Kumagai M, Shioda Y, Nozawa K, Kitoh H]
通讯作者:
Kitoh H
共 29 条
The establishment of new cell therapy for bone regeneration by transplantation of culture expanded bone marrow cells and platelet rich plasma
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批准号:19591755
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:KITOH Hiroshi
-
依托单位:
Bone tissue engineering by transplantation of culture expanded bone marrow cells and platelet rich plasma
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批准号:17591563
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:KITOH Hiroshi
-
依托单位:
Acceleration of bone regeneration by overexpression of vascular endothelial growth factor gene in bone marrow mesenchymal stem cells
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批准号:15591573
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2003
-
负责人:KITOH Hiroshi
-
依托单位:
海外基金