Abnormal DNA double-strand break repair in human malignant soft tissue tumors
Abnormal DNA double-strand break repair in human malignant soft tissue tumors
批准号:
21591926
负责人:
TANAKA Kazuhiro
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Chromosomal translocations to generate chimaeric fusion genes are a hallmark of a group of soft tissue sarcomas. Whereas the pathogenic significance of these anomalous genes has been generally established in tumours of this category, the origin of gene fusion still remains unknown. Using DNA microarrays, we observed expression of the genes participating in the DNA double-strand break repair pathways. In two cell lines established from human Ewing's sarcomas, their expression was uniformly elevated. Aberrant expression of double-strand break repair genes may be generally associated with tumourigenesis by the chimaeric fusion genes.
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骨肉腫の臨床試験への挑戦
骨肉瘤临床试验面临的挑战
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[平賀博明, 田仲和宏, 井樋栄二, 米本司, 比留間徹, 大野貴敏, 中山富貴, 尾崎敏文, 永田見生, 岩本幸英]
通讯作者:
岩本幸英
DOI:
10.1093/jjco/hyn153
发表时间:
2009-04-01
期刊:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
影响因子:
2.4
作者:
[Tanaka, Kazuhiro, Kawamoto, Hiroshi, Iwamoto, Yukihide]
通讯作者:
Iwamoto, Yukihide
悪性軟部腫瘍における化学療法の意義
恶性软组织肿瘤化疗的意义
DOI:
--
发表时间:
2012
期刊:
癌と化学療法
影响因子:
--
作者:
[関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 田仲和宏]
通讯作者:
田仲和宏
非円形細胞軟部肉腫に対する化学療法
非圆细胞软组织肉瘤的化疗
DOI:
--
发表时间:
2010
期刊:
整形外科
影响因子:
--
作者:
[関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 関矢一郎, 田仲和宏, 関矢一郎, 田仲和宏]
通讯作者:
田仲和宏
骨腫瘍は集学治療だがどうしてこんなに複雑なのか? EBM癌化学療法・分子標的治療法
骨肿瘤多学科治疗,EBM癌症化疗/分子靶向治疗为何如此复杂?
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[田仲和宏, 岩本幸英, Kouji Naruse, 関矢一郎, 田仲和宏]
通讯作者:
田仲和宏
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QCD study of B meson decays : universal design of QCD factorizationand its accuracy
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Study of high Intensity Beam Handling
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Analysis of the mechanisms of the proteolysis of p27 in Ewing's sarcoma and its clinical application.
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Identification and characterization of ice nucleators transmitting from prey to predator
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QCD study of B meson decays: investigation of dynamical gluon effects inside B meson
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Application of antisense oligonucleotides for EWS-Flil in Ewing's sarcoma.
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