A role of glycine transporter on spinal dorsal horn neuron through the pain sensation produced by neuropathic pain model

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We investigated the effect of glycine transporter in spinal dorsal horn neuron, but we could not find that effect. Therefore, we have demonstrated that d-serine in spinal dorsal horn neuron has two distinct actions, one is an excitatory action mediated by NMDA receptor, the other is an inhibitory action mediated by glycine receptor. Interestingly, the excitatory action by d-serine after peripheral nerve injury was more sensitive than physiological condition, whereas its inhibitory action after peripheral nerve injury was less than naive one.