Evaluation of neuroendocrine in primary afferent neuron of neuropathic pain

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Behavior tests, which study on hypersensitivity to thermal stimulation, have indicated the effect of water in CCI model. Primary afferent neurons innervated to mouse hind-paw were labeled and discriminated by using DiI. Capsaicin sensitivity of hind-paw neurons suggested that TRPV1 might have relatively little contribution for nociception and neurogenic inflammation. Recently, TRPA1 inhibition was reported to reduce neurogenic inflammation, which suggests that TRPA1 might be involved in neuroendocrine in primary afferents.