Identification of molecules associated with intravesical recurrence of non-muscle invasive bladder cancer and the development of novel therapeutic strategy based on the molecular mechanism

鉴定与非肌层浸润性膀胱癌膀胱内复发相关的分子并基于分子机制开发新的治疗策略

• 批准号: 21592045
• 负责人: MIYAKE Hideaki
• 金额: $ 2.83万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592045/
• 关键词: 表在性膀胱癌; 再発; 細胞周期; 細胞接着; EMT; siRNA; HSP70; 血管新生; カドヘリン; p27; β4 interin; eithelial-to-mesenhymal transition; 免疫組織化学染色; 再発予防; β4 integrin; epithelial-to-mesenhymal transition

Through the evaluation of molecules associated with cell cycle, cell adherence and EMT, we developed predictive systems for intravesical recurrence of non-muscle invasive bladder cancer. In addition, we suggested the usefulness of novel therapeutic strategy targeting these molecules for preventing intravesical recurrence of non-muscle invasive bladder cancer.

通过评估与细胞周期、细胞粘附和EMT相关的分子，我们开发了非肌层浸润性膀胱癌膀胱内复发的预测系统。此外，我们提出了针对这些分子的新的治疗策略，用于预防非肌层浸润性膀胱癌的膀胱内复发的有用性。

项目成果

Growth inhibition and chemosensitization in human bladder cancer KoTCC-1 cells by siRNA targeting heat shock protein-70

靶向热休克蛋白70的siRNA对人膀胱癌KoTCC-1细胞的生长抑制和化疗增敏

• 发表时间: 2010
• 作者: Hideaki Miyake;Tomoaki Terakawa;Iori Sakai;Junya Furukawa;Yuji Kusuda;Mototsugu Muramaki;Atsushi Takenaka;Masato Fujisawa
• 通讯作者: Masato Fujisawa

Expression of cell cycle-associated proteins in superficial bladder cancer : correlation with intravesical recurrence following transurethral resection

浅表性膀胱癌中细胞周期相关蛋白的表达：与经尿道切除术后膀胱内复发的相关性

• 发表时间: 2009
• 作者: Miyake H;他5名(2番目)
• 通讯作者: 他5名(2番目)

Expression profile of E-cadherin and N-cadherin in non-muscle-invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection

• DOI: 10.1016/j.urolonc.2010.01.005
• 发表时间: 2012-03-01
• 期刊: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
• 影响因子: 2.7
• 作者: Muramaki, Mototsugu;Miyake, Hideaki;Fujisawa, Masato
• 通讯作者: Fujisawa, Masato

Expression of integrin proteins in non-muscle invasive bladder cancer : significance of intravesical recurrence following transurethral resection

整合素蛋白在非肌层浸润性膀胱癌中的表达：经尿道切除术后膀胱内复发的意义

• 发表时间: 2010
• 期刊: BJU International
• 影响因子: 4.5
• 作者: Miyake H;(他5名;2番目)
• 通讯作者: 2番目)