Investigation of mechanism mediating resistant phenotype of renal cell carcinoma to tyrosine kinase inhibitors and development of novel therapy to ovetrcome its resistance

肾细胞癌酪氨酸激酶抑制剂耐药表型机制研究及耐药新疗法的开发

• 批准号: 24592389
• 负责人: MIYAKE Hideaki
• 金额: $ 3.41万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24592389/
• 关键词: 腎細胞癌; チロシンキナーゼ阻害剤; MAP kinase; Akt; 耐性獲得

项目成果

Characterization of mechanism involved in acquired resistance to sorafenib in a mouse renal cell cancer RenCa model

• DOI: 10.1007/s12094-013-1151-9
• 发表时间: 2014-09-01
• 期刊: CLINICAL & TRANSLATIONAL ONCOLOGY
• 影响因子: 3.4
• 作者: Harada, K.;Miyake, H.;Fujisawa, M.
• 通讯作者: Fujisawa, M.

Expression of molecular markers associated with the mammalian target of rapamycin pathway in nonmetastatic renal cell carcinoma: Effect on prognostic outcomes following radical nephrectomy.

• DOI: 10.1016/j.urolonc.2013.07.014
• 发表时间: 2014
• 期刊: Urologic oncology
• 作者: Masatomo Nishikawa;H. Miyake;K. Harada;M. Fujisawa

Significance of circulating matrix metalloproteinase-9 to tissue inhibitor of metalloproteinases-2 ratio as a predictor of disease progression in patients with metastatic renal cell carcinoma receiving sunitinib

• DOI: 10.1016/j.urolonc.2014.01.016
• 发表时间: 2014-07-01
• 期刊: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
• 影响因子: 2.7
• 作者: Miyake, Hideaki;Nishikawa, Masatomo;Fujisawa, Masato
• 通讯作者: Fujisawa, Masato