GDF-9 as a possible marker for oocyte quality, based on studies of gene expression in rat preantral follciles.

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Polycystic ovary syndrome(PCOS) is commonly associated with ovulatory dysfunction with consequent subfertility, miscarriage, and poor oocyte quality. We have developed an in vitro PCOS model by using rat preantral follicles, and indicated that the gene expressions of oocyte GDF-9 and granulosa FSH receptor are suppressed in this PCOS model. The present results suggest that GDF-9 is a possible marker of oocyte quality in PCOS patients.