Melatonin protects oocyte and granulosa cellsfrom reactive oxygen species during ovulation process within the follicle

褪黑激素在卵泡内的排卵过程中保护卵母细胞和颗粒细胞免受活性氧的影响

• 批准号: 21592099
• 负责人: TAMURA Hiroshi
• 金额: $ 3万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592099/
• 关键词: メラトニン; 活性酸素; 卵子; 顆粒膜細胞; 酸化ストレス; 卵; 卵胞

Reactive oxygen species(ROS) are produced within the fbllicle especially during the ovulatory process. We examined whether melatonin acts as an anti-oxidant within follicles and protects oocytes and granulosa cells from oxidative stress. Melatonin, secreted by the pineal gland, is taken up into thefollicular fluid from the blood. ROS produced within the follicles, especially during the ovulation process, were scavenged by melatonin, and reduced oxidative stress may be involved in oocyte maturation, embryo development and luteinaization of granulosa cells. Our clinical study demonstrated that melatonin treatment for infertile women increases intra-fbllicular melatonin concentrations, reduces intra-follicular oxidative damage and elevates fertilization and pregnancy rates. Melatonin treatment also improves progesterone production by corpus luteum in infertile women with luteal phase defect.

活性氧（ROS）在卵泡内产生，特别是在排卵过程中。我们研究了褪黑激素是否在卵泡内起到抗氧化剂的作用，并保护卵母细胞和颗粒细胞免受氧化应激。褪黑素由松果体分泌，从血液中进入卵泡液。卵泡内产生的活性氧，特别是在排卵过程中，被褪黑激素清除，氧化应激的减少可能参与卵母细胞成熟、胚胎发育和颗粒细胞的黄体化。我们的临床研究表明，褪黑素治疗不孕妇女可增加卵泡内褪黑素浓度，减少卵泡内氧化损伤，提高受精率和妊娠率。褪黑素治疗也改善黄体期缺陷不孕妇女黄体黄体酮的产生。

项目成果

The role of melatonin as an antioxidant in the fbllicle

褪黑激素作为纤维中抗氧化剂的作用

• 发表时间: 2012
• 期刊: N. J Ov Res
• 作者: Tamura H;Takasaki A;Taketani T;Tanabe M;Kizuka F;Lee L;Tamura I;Maekawa R;Asada H;Yamagata Y;Sugino
• 通讯作者: Sugino

Differential effects of progesterone on COX-2 and Mn-SOD expressions are associated with histone acetylation status of the promoter region in human endometrial stromal cells.

• DOI: 10.1210/jc.2010-2489
• 发表时间: 2011-05
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: I. Tamura;T. Taketani;L. Lee;Fumie Kizuka;K. Taniguchi;R. Maekawa;H. Asada;H. Tamura;N. Sugino

Protective role of melatonin in progesterone production by human luteal cells

• DOI: 10.1111/j.1600-079x.2011.00878.x
• 发表时间: 2011-09-01
• 期刊: JOURNAL OF PINEAL RESEARCH
• 影响因子: 10.3
• 作者: Taketani, Toshiaki;Tamura, Hiroshi;Sugino, Norihiro
• 通讯作者: Sugino, Norihiro

生殖機能調節の新しい視点10.メラトニンの卵巣機能調節

生殖功能调节新视角十、褪黑素调节卵巢功能

• 发表时间: 2010
• 期刊: 産科と婦人科
• 作者: 田村博史;杉野法広
• 通讯作者: 杉野法広

-メラトニン研究の最近の進歩と医療への応用-パネルディスカッション『私のメラトニン使用経験から』

-褪黑素研究和医学应用的最新进展-小组讨论“根据我使用褪黑素的经验”

• 发表时间: 2011
• 作者: 住吉香恵子;川越靖之;鮫島浩;池ノ上克;田村博史
• 通讯作者: 田村博史