The role of micro-RNA in carcinogenesis and development of uterine papillary serous carcinoma(UPSC)

micro-RNA在子宫乳头状浆液性癌(UPSC)发生、发展中的作用

• 批准号: 21592120
• 负责人: NAGASE Satoru
• 金额: $ 3万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592120/
• 关键词: 子宮体癌; 子宮体部漿液性腺癌; 類内膜腺癌; マイクロRNA; 発現プロファイル; 子宮体がん; 標的遺伝子

We compared miRNA expression levels in uterine papillary serous carcinoma (UPSC)with the levels in endometrial endometrioid adenocarcinoma (EEC)and normal endometria. Eight miRNAs were identified as having aberrant down-regulation specific to UPSC with miR-34b being most pronounced. Ectopic expression of miR-34b inhibited cell growth, migration, and most notably invasion. These effects are likely mediated by the downstream target of miR-34b, the proto-oncogene MET, a known prognostic factor in endometrial carcinomas. The expression of MET was reduced following the restoration of miR-34b in cell lines. In summary, our data suggest that miR-34b plays a role in the molecular pathogenesis of ESC.

我们比较了子宫乳头状癌癌（UPSC）中的miRNA表达水平与子宫内膜子宫内膜腺癌（EEC）和正常内膜的水平。八个miRNA被确定为对UPSC的异常下调，而miR-34b最为明显。 miR-34b的异位表达抑制了细胞生长，迁移和最著名的侵袭。这些作用可能是由miR-34b的下游靶标，原始癌基因MET是子宫内膜癌的已知预后因素。在细胞系中miR-34b恢复后，MET的表达降低。总而言之，我们的数据表明miR-34b在ESC的分子发病机理中起作用。

项目成果

Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas

• DOI: 10.1111/j.1349-7006.2009.01385.x
• 发表时间: 2010-01-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Hiroki, Eri;Akahira, Jun-ichi;Yaegashi, Nobuo
• 通讯作者: Yaegashi, Nobuo

子宮体部漿液性腺癌(UPSC)におけるマイクロRNAの発現異常および機能の検討

子宫体浆液性腺癌（UPSC）中 microRNA 异常表达和功能的检测

• 发表时间: 2010
• 作者: 岡本直樹;杉下陽堂;渡部真梨;吉岡伸人;西島千絵;浜田直美;高橋則行;石塚文平;新倉仁;永瀬智
• 通讯作者: 永瀬智

子宮体部漿液性腺癌においてmicroRNA-34bは癌抑制的な役割をもつ可能性がある

microRNA-34b可能对子宫体浆液性腺癌具有抑癌作用

• 发表时间: 2010
• 作者: 廣木恵理;赤平純一;鈴木史彦;永瀬智;伊藤潔;笹野公伸;八重樫伸生
• 通讯作者: 八重樫伸生

Japan Society of Gynecologic Oncology. Evidence-based guidelines for treatment of uterine body neoplasm in Japan : Japan Society of Gynecologic Oncology (JSGO)2009 edition

日本妇科肿瘤学会。

• 发表时间: 2010
• 期刊: Int J Clin Oncol
• 影响因子: 3.3
• 作者: Nagase S;他28名
• 通讯作者: 他28名

MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma

• DOI: 10.1002/ijc.27345
• 发表时间: 2012-08-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Hiroki, Eri;Suzuki, Fumihiko;Yaegashi, Nobuo
• 通讯作者: Yaegashi, Nobuo