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Analysis of ovarian tumourigenesis due to activators for histone deacetylases(HDACs) that are highly overexpressed in cancers

Analysis of ovarian tumourigenesis due to activators for histone deacetylases(HDACs) that are highly overexpressed in cancers
癌症中高度过度表达的组蛋白脱乙酰酶 (HDAC) 激活剂引起的卵巢肿瘤发生分析
批准号：
21592129
负责人：
HIGASHITSUJI Hisako
金额：
$2.91万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592129/
关键词：
ガンキリンHSCOヒストン脱アセチル化酵素卵巣癌活性化因子HDAC1SIRT1がん抑制遺伝子ヒストン脱アセチル化酵素

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英文摘要
Protooncogene Gankyrin is overexpressed in ovarian cancer. Gankyrin accelerates to degrade pRb protein. Gankyrin inhibits the interaction of p16INK4a with cdk4. Gankyrin enhances to degrade p53 protein by MDM2. Gankyrin suppresses the activity of NFkappaB, partly due to recruitment of SIRT1 histone deacetylase to NFkappaB protein. HSCO gene is overexpressed in ovarian cancer. HSCO inhibits the activity of p53 due to recruitment of HDAC1 histone deacetylase to p53 protein. Gankyrin and HSCO activate the activity of HDACs. These enhanced activities of HDACs accelerate to grow cancer cells more aggressively. The activities of invasion and metastasis are enhanced due to these activated HDACs. Nicotinamide suppresses SIRT1 activity. TSA(Trichostatin A) inhibits HDAC1 activity. These HDAC inhibitors suppress the growth, invasion, and metastasis of cancer cells.
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Adriamycin Enhances Proteasome-Mediated Generation of the Proapoptotic Processed Form of MAGE-A4 in Hepatoma Cells
DOI： 10.1159/000334307
发表时间： 2011-12
期刊： Oncology
影响因子： 3.5
作者： [T. Sakurai;M. Kudo;K. Itoh;U. Ryu;H. Higashitsuji;J. Fujita]
通讯作者： T. Sakurai;M. Kudo;K. Itoh;U. Ryu;H. Higashitsuji;J. Fujita
Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance
DOI： 10.1002/ijc.23106
发表时间： 2008-01-15
期刊： INTERNATIONAL JOURNAL OF CANCER
影响因子： 6.4
作者： [Ortiz, Cristian M., Ito, Tetsuo, Shimada, Yutaka]
通讯作者： Shimada, Yutaka
Association of gankyrin protein expression with early clinical stages and IGFBP-5 expression in human hepatocellular carcinoma.
gankyrin 蛋白表达与人肝细胞癌早期临床分期和 IGFBP-5 表达的关联。
DOI： --
发表时间： 2008
期刊： Hepatology 47(2)
影响因子： --
作者： [Umemura A, Itoh Y, Itoh K, Yamaguchi K, Nakajima T, Higashitsuji H, Onoue H, Fukumoto M, Okanoue T, Fujita J.]
通讯作者： Fujita J.
MDM2 is a novel E3 ligase for HIV-1 Vif.
DOI： 10.1186/1742-4690-6-1
发表时间： 2009-01-07
期刊： RETROVIROLOGY
影响因子： 3.3
作者： [Izumi, Taisuke, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Higashitsuji, Hiroaki, Itoh, Katsuhiko, Io, Katsuhiro, Matsui, Masashi, Iwai, Kazuhiro, Kondoh, Hiroshi, Sato, Toshihiro, Tomonaga, Mitsunori, Ikeda, Satoru, Akari, Hirofumi, Koyanagi, Yoshio, Fujita, Jun, Uchiyama, Takashi]
通讯作者： Uchiyama, Takashi
共 7 条
    Mechanism of ovarian carcinogenesis due to 26S proteasome activation by protooncogene gankyrin mononeddylation
    • 批准号：
      24592514
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.33万
    • 财政年份：
      2012
    • 负责人：
      HIGASHITSUJI Hisako
    • 依托单位：
      Kyoto University
    Analysis of ovarian carcinogenesis due to monoubiquitylation of gankyrin that is one of proteasome-interacting -proteins (PIPs)
    • 批准号：
      19591931
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.91万
    • 财政年份：
      2007
    • 负责人：
      HIGASHITSUJI Hisako
    • 依托单位：
      Kyoto University
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