A new development of pathological breakthrough and treatment strategy for eosinophilic otitis media

探讨嗜酸性中耳炎（EOM）的临床危险因素，建立EOM的诊断标准。此外，我们还研究了嗜酸性中耳炎（EOM）患者和新建立的EOM动物模型中耳标本中骨膜蛋白（一种细胞外基质蛋白）的定位。伴有/不伴有哮喘的EOM患者的中耳切片中观察到骨膜蛋白阳性免疫染色。在动物模型中，也观察到对骨膜素的免疫反应性。提示骨膜蛋白在EOM中耳上皮下纤维化中起重要作用。

We investigated the clinical risk factors of Eosinophlic Otitis Media (EOM) and established the diagnostic criteria of EOM. Moreover, we investigated the localization of periostin, an extracellular matrix protein, in middle ear specimens of eosinophlic otitis media (EOM) patients accompanied and of a newly constructed animal model for EOM. Periostin-positive immunostaining was observed in the middle ear sections obtained from the EOM patients with/without asthma. In the animal model, immunoreactivity for periostin was also seen. These results suggested that periostin plays an important role in subepithelial fibrosis in the middle ear of EOM.