Mechanism of EBV induced salivary gland disorder via TLR
Mechanism of EBV induced salivary gland disorder via TLR
批准号:
21592347
负责人:
INOUE Hiroko
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The salivary gland epithelial cells, HSY cells, were transfected with CD21-HA plasmid. EBV positive-B cell line, Akata, was cocultured with CD21-HSY cells for establishment of EBV positive salivary gland epithelial cells. The expression plasmids, TLR3, TLR8, and TLR9-HA, were prepared. To study of BAFF transcription, BAFF promoter region was flanked with luciferase coding region, BAFF-Luc. BALB/c mice were immunized with nuclear extract from Akata, and will be evaluated with ELISA for SSB/La, which was established with recombinant SSB/La-GST protein.
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DOI:
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发表时间:
2011
期刊:
影响因子:
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作者:
[山村優花, 美島健二, 山田浩之, 井上裕子, 濱田良樹, 斎藤一郎]
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斎藤一郎
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DOI:
--
发表时间:
2011
期刊:
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[美島健二, 檜枝洋記, 伊藤正孝, 吉田哲, 川北哲也, 井上裕子, 坪田一男, 斎藤一郎]
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DOI:
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发表时间:
2010
期刊:
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[美島健二, 鎌谷宇明, 山田浩之, 井出文雄, 井上裕子, 斎藤一郎, 美島健二]
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美島健二
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DOI:
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发表时间:
2009
期刊:
影响因子:
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作者:
[田井良憲, 井上裕子, 梁洪淵, 森戸光彦, 美島健二, 斎藤一郎]
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斎藤一郎
The role of fractalkine as accelerating factor on the autoimmune exocrinopathy in mice
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DOI:
--
发表时间:
2009
期刊:
Invest. Ophthalmol. Vis. Sci
影响因子:
--
作者:
[Tsubota K, Nishiyama T, Mishima K, Inoue H, Doi T, Hattori Y, Kodama T, Higuchi A, Hayashi Y, Saito I]
通讯作者:
Saito I
共 15 条
Research of biomarker to reflect the dietary habit and nutritional status of adolescence and development of nutrition education program.
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批准号:21700762
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2009
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负责人:INOUE Hiroko
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依托单位:
Pathogenesis of Epstein-Barr virus on tissue specific autoimmune disease in humanized mice
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The mechanism of exocrine gland disorder through estrogen and/or endocrine disruptors
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批准号:16591846
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Clarification of mechanism of cell degeneration using Drosophila and mouse mutant
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批准号:02680205
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1990
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负责人:INOUE Hiroko
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依托单位:
海外基金