Molecular dissection of transcription factor on bone formation

点击翻译按钮获取中文摘要

To elucidate the in vivo function of Osr1, we generated transgenic mice overexpressing Osr1. Osr1 transgenic mice demonstrated delayed cranial sutures. Examinations of newborn Osr1 transgenic mice skeletons stained with alcian blue and alizarin red showed abnormalities in the skull and skeletal elements. Calvarial osteoblasts obtained from Osr1 transgenic mice showed abnormalities in osteoblast differentiation and proliferation, confirming that Osr1 is required for osteogenesis. Our genetic observations showed that the Osr1 gene plays a key role in osteoblastic cell proliferation.