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Studies on the induction and protective effect of nerve cell differentiation by a newly synthesized NAD discovered in the yeast Candida

酵母念珠菌中新合成的 NAD 对神经细胞分化的诱导和保护作用的研究

基本信息

批准号：
21592379
负责人：
KAMINISHI Hidenori
金额：
$ 2.91万
依托单位：
Fukuoka Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592379/
关键词：
酵母 Candida NAD 神経細胞分化誘導

项目摘要

Since it discovered that the substance which expands the projection of a nerve cell from Candida yeast, and supports growth existed, chemical synthesis was performed based on the composition and structure(with the similar object of NAD, a molecular weight is 663), and synthetic compound was obtained. The obtained compound expanded notably the projection of the rat central-nerves cell and the human origin nerve cell(NB-1). Moreover, it was checked that a series of gene clusters which participate in extension of a nerve projection of any cell, substance transportation, microtubule stability, etc. are revealed strongly.Compound which is proposed in this research differs from any which are reported so far completely, peptide and the lipid is not included, it is possible to synthesize easily. The synthetic compound brought about extension of a projection of a nerve cell, and extension of survival of the cells which is in a starvation situation. As for this result, protection of the nerve cell which has a synthetic compound under various diseases of the nervous system, especially an ischemia situation, restoration, reproduction, etc. are expected to demonstrate an effect, and leading to creation of a new diseases-of-the-nervous-system curative medicine is suggested. Patent application No.2010-154279 PCT : PCT/JP2011/002319The applicable field of the compound proposed by this research is as follows. Diseases-of-the-nervous-system medical treatment, medicine development, regenerative medicine, a cell technology, neuronal physiology, neuroscience, etc.

由于发现存在扩大来自假丝酵母的神经细胞突起并支持生长的物质，因此基于组成和结构进行化学合成（与NAD类似，分子量为663），并获得合成化合物。所获得的化合物显著地扩展了大鼠中枢神经细胞和人源神经细胞（NB-1）的投射。此外，还发现了一系列参与任何细胞的神经投射的延伸、物质运输、微管稳定性等的基因簇。本研究中提出的化合物与迄今为止报道的任何化合物都完全不同，不包括肽和脂质，可以容易地合成。合成化合物带来了神经细胞突起的延长，以及处于饥饿状态的细胞存活的延长。对于该结果，预期在各种神经系统疾病，特别是缺血情况下，具有合成化合物的神经细胞的保护、恢复、再生等方面表现出效果，并建议产生新的神经系统疾病治疗药物。专利申请号2010 -154279 PCT：PCT/JP 2011/002319本研究提出的化合物的应用领域如下。神经系统疾病的医疗、医学开发、再生医学、细胞技术、神经元生理学、神经科学等