Research on nerve nutrition and a protection action of the new water solubility substance obtained from Candida albicans.

白色念珠菌新型水溶性物质的神经营养及保护作用研究。

• 批准号: 16591851
• 负责人: KAMINISHI Hidenori
• 金额: $ 1.86万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591851/
• 关键词: Candida albicans; differentiation induction; neurotrophy; nerve protection; NAD; chemical synthesis; Sepabeads SP207; SephadexLH-20; 低分子物質

This research was carried out to clarify the composition analysis the chemical structure of nerve protection and nutritional factor which located in the intracellular of Candida albicansChemical composition and structure analysis were carried out by the execution of mass spectrometry analysis and NMR analysis using the isotope variously in respect of the material which separated from the fungus. As this result, the result that that the material got from Candida albicans is hydrophilic and that the molecular weight is 663, and that it is analog (β-L-NAD) of the new NAD from result of analysis was indicated was obtained.By four passing steps of the result of examining the method of chemical synthesis based on result of analysis, the specified substance should be got, and the synthesis was started. At present, the second step is the progressing, and the chemical synthesis sample will be got in the near future.

本研究旨在阐明白假丝酵母胞内神经保护因子和营养因子的组成分析、化学结构，并对分离得到的物质进行了质谱分析和核磁共振分析。根据该结果，从白色念珠菌得到的物质是亲水性的，分子量为663，根据分析结果表明它是新NAD的类似物（β-L-NAD）。通过基于分析结果检查化学合成方法的结果的四个步骤，应该得到特定物质，并开始合成。目前，第二步正在进行中，近期将获得化学合成样品。

项目成果

Transcriptional profiling of the early stage of germination in Candida albicans by real-time RT-PCR.

通过实时 RT-PCR 对白色念珠菌萌发早期阶段进行转录分析。

• 发表时间: 2004
• 期刊: FEMS Yeast Res 5
• 作者: Toyoda M.;Cho T.;Kaminishi H.et al.
• 通讯作者: Kaminishi H.et al.

カンジダ・アルビカンス由来の神経細胞の活性化・保護剤

源自白色念珠菌的神经细胞活化/保护剂

• 发表时间: 2004

Antifungal activity of DNA-lipid complexes and DNA-lipid films against candida species

• DOI: 10.1002/jbm.a.30394
• 发表时间: 2006-01-01
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
• 影响因子: 4.9
• 作者: Inoue, Y;Fukushima, T;Okahata, Y
• 通讯作者: Okahata, Y

植物精油を添加した歯磨剤の抗菌作用

含植物精油的牙膏的抗菌作用

• 发表时间: 2005
• 期刊: 医学と生物学 150(3)
• 作者: 上西秀則;小倉理恵子;長 環;豊田美香;井上勇介;松永勝政
• 通讯作者: 松永勝政

Transcriptional profiling of the early stage of germination in Candida albicans by real-time RT-PCR

通过实时 RT-PCR 对白色念珠菌萌发早期的转录谱进行分析

• 发表时间: 2004
• 期刊: FEMS Yeast Research 5
• 作者: Toyoda M.;Cho T.et al.
• 通讯作者: Cho T.et al.