Chronological and morphological analysis of microcirculation in transgenic mouse model with odontogenic cystic les ion.

牙源性囊性病变转基因小鼠模型微循环的时间和形态学分析。

• 批准号: 21592384
• 负责人: ONODERA Ken
• 金额: $ 1.25万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592384/
• 关键词: 歯学; 病理学; 遺伝子; 歯原性嚢胞性病変; 微小循環

Preliminary, we examined jaw cysts in heterozygous ptc knockout mouse. Mandibular cysts were often histologically detected in the alveolar bones or periodontal ligaments of the molars, but maxillary cysts were not detected. And we analyzed the expression of CD31, CD34 and D2-40 in human odontogenic cystic lesions of dentigerous cysts, radicular cysts and keratocystic odontogenic tumors. Distinctly positive staining for D2-40 was found in lymphatic vessels located in the cystic walls. Small blood vessels stained for CD31 and CD34 were also present in the cystic walls. Especially, numerous lymphatic vessels and blood vessels were present in the radicular cysts.

初步，我们检查了杂合子ptc基因敲除小鼠的颌骨囊肿。组织学检查发现下颚囊肿常位于臼齿的牙槽骨或牙周韧带，但未发现上颚囊肿。并分析了CD 31、CD 34和D2-40在牙源性囊性病变含牙囊肿、根尖囊肿和角化囊性牙源性肿瘤中的表达。D2-40在位于囊壁的淋巴管中呈明显阳性染色。囊壁中还存在CD 31和CD 34染色的小血管。特别是根性囊肿内存在大量淋巴管和血管。

项目成果

「歯原性. 胞性病変におけるサイトケラチン7, 20およびカルレチニンの発現に関する免疫組織学的検討」

“牙源性牙槽病变中细胞角蛋白7、20和钙结合蛋白表达的免疫组织学研究”

• 发表时间: 2010
• 作者: 小野寺健;熊本裕行
• 通讯作者: 熊本裕行