Epithelotropism of effector cells in immune disorders of the oral mucosa

在大鼠模型中研究了效应细胞的向上皮性。在卫星定位诱导的口腔病变中，上皮角质形成细胞上ICAM-1表达的诱导导致CD 8+细胞迁移到上皮中。苔藓样病变的特征是上皮基底膜周围II+和ED 1+细胞的强烈浸润，显示自身抗体的沉积。这些发现提供了深入了解效应细胞在口腔粘膜病变中的病理生理作用。

Epithelotropism of effector cells were studied in rat models of satellitosis-induced and lichenoid oral mucosal disorders. In the satellitosis-induced oral lesion, the induction of ICAM-1 expression on epithelial keratinocytes leads to the migration of CD8+cells into the epithelium. The lichenoid lesion is characterized by intense infiltration of class II+and ED1+cells around the epithelial basement membrane showing deposition of autoantibodies. These findings provided insights into the pathophysiological roles of effector cells in oral mucosal lesions.