Response of irradiated tissue supporting implant prosthesis under the compressing force.

支撑种植体假体的受辐射组织在压缩力下的响应。

• 批准号: 21592497
• 负责人: TOMOTAKE Yoritoki
• 金额: $ 2.91万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592497/
• 关键词: 歯学; インプラント補綴; 放射線障害; 骨芽細胞様細胞; 持続的圧縮力

The aim of this study was to estimate the response of the irradiated tissue added the compressing force. Mouse osteoblast-like cells were compressed directly after the irradiation, gene expression of apoptosis channel was examined. Activation of caspase significant increased with stronger radiation, and decreased with the compressed force. It was recognized that gene expression related to prevention of apoptosis were increased under the compressing force.

本研究的目的是估计辐照组织在压缩力作用下的反应。照射后直接压缩小鼠成骨样细胞，检测凋亡通道基因表达。caspase的活化随辐射强度的增加而增加，随压缩力的增加而降低。已经认识到，在挤压力下，与防止细胞凋亡相关的基因表达增加。