New approach to the mechanism of the pain by orthodontic tooth movement
New approach to the mechanism of the pain by orthodontic tooth movement
批准号:
21592596
负责人:
MURAKAMI Takashi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
正畸牙齿移动引起疼痛。以往对疼痛发生机制的研究主要集中在神经细胞上。本研究以神经元周围的胶质细胞为研究对象,探讨胶质细胞如何参与正畸牙移动疼痛的发生发展。本研究不仅揭示了正畸牙移动过程中激活的胶质细胞的时间分布,而且揭示了CGRP和VR1在中枢神经系统中的作用。
英文摘要
Orthodontic tooth movement evokes a pain. As for the past research to the mechanism of the pain, the focus has been placed on neural cells. This research newly focused on glial cells surrounding neurons, and searched how glial cells involved in the development of the pain by orthodontic tooth movement. This research revealed not only temporal distribution of activated glial cells but also the involvement of CGRP and VR1 in central nervous system during orthodontic tooth movement.
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期刊:
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