The involvement of CCL3, CCR5 in inflammatory and neuropathic pain

研究了Seltzer模型小鼠周围神经、背根神经节（DRG）和背角中巨噬细胞和小胶质细胞的极性和来源。损伤坐骨神经中，M1巨噬细胞数量在术后3天达到高峰。这些巨噬细胞大多来自骨髓。3~7天后。DRG和背角的M2巨噬细胞和M1小胶质细胞增多。分别。这些细胞被认为是常驻的，因为EGFP阳性的巨噬细胞和小胶质细胞在手术后3周首次被检测到。

Polarity and origins of macrophages and microglia in peripheral nerves, dorsal root ganglia(DRG) and dorsal horns were examined in Seltzer model mice. In injured sciatic nerves, the number of M1 macrophages got its peak at 3days after surgery. Most of these macrophages were shown to be derived from the bone marrow. After 3～7 days. M2 macrophages and M1 microglia were increased in the DRG and dorsal horns. respectively. These cells were considered to be resident, since EGFP positive macrophages and microglia were first detected at 3 weeks after surgery.