Development of a behavior modification program using genetic information

利用遗传信息开发行为矫正计划

• 批准号: 21650174
• 负责人: KATOH Takahiko
• 金额: $ 1.98万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21650174/
• 关键词: 健康教育; 行動変容; 遺伝子診断; 遺伝子多型; 肥満; 高血圧; 飲酒; 高血圧症

Currently, in the field of occupational health, management of lifestyle disease has become one of most important issues. In addition, disease susceptibility, which indicates vulnerability to various environmental factors, has been elucidated at the gene level using molecular epidemiology. In this study, we used factory workers, from whom it is relatively easy to receive lifestyle and health examination data, as the target population. We explored the relevance of candidate genes and lifestyle-related diseases such as obesity and hypertension. Additionally, this study was conducted to examine whether the genetic diagnosis of aldehyde dehydrogenase 2, which defines drinking behavior is useful in supporting those who want to decrease their alcohol intake. The weekly alcohol intake tended to decrease in the notified group, although the result was not significant.

当前，在职业健康领域，生活方式病的管理已成为最重要的问题之一。此外，疾病易感性表明对各种环境因素的脆弱性，已利用分子流行病学在基因水平上得到阐明。在本研究中，我们以相对容易获得生活方式和健康检查数据的工厂工人作为目标人群。我们探讨了候选基因与肥胖和高血压等生活方式相关疾病的相关性。此外，这项研究的目的是检验乙醛脱氢酶 2（定义饮酒行为）的基因诊断是否有助于支持那些想要减少酒精摄入量的人。通知组的每周酒精摄入量趋于减少，尽管结果并不显着。

项目成果

ADRB3 Polymorphism Associated with BMI Gain in Japanese Men

ADRB3 多态性与日本男性 BMI 增加相关

• 发表时间: 2012
• 期刊: International Journal of Experimental Diabetes Research
• 作者: S. Takeuchi;T. Katoh;Takenori Yamauchi;Y. Kuroda
• 通讯作者: Y. Kuroda