Development of a behavior modification program using genetic information

目前，在职业卫生领域，生活方式疾病的管理已成为最重要的问题之一。此外，疾病的易感性，即对各种环境因素的易感性，已经用分子流行病学在基因水平上得到了阐明。在本研究中，我们选择了相对容易获得生活方式和健康检查数据的工厂工人作为目标人群。我们探索了候选基因与生活方式相关疾病（如肥胖和高血压）的相关性。此外，这项研究的目的是检查醛脱氢酶2的基因诊断是否对那些想要减少酒精摄入量的人有用，醛脱氢酶2定义了饮酒行为。在被告知的小组中，每周的酒精摄入量倾向于减少，尽管结果并不显著。

Currently, in the field of occupational health, management of lifestyle disease has become one of most important issues. In addition, disease susceptibility, which indicates vulnerability to various environmental factors, has been elucidated at the gene level using molecular epidemiology. In this study, we used factory workers, from whom it is relatively easy to receive lifestyle and health examination data, as the target population. We explored the relevance of candidate genes and lifestyle-related diseases such as obesity and hypertension. Additionally, this study was conducted to examine whether the genetic diagnosis of aldehyde dehydrogenase 2, which defines drinking behavior is useful in supporting those who want to decrease their alcohol intake. The weekly alcohol intake tended to decrease in the notified group, although the result was not significant.