Risk assessment of cancer risk based on life-style and genetic diagnosis -Aiming at the behavioral of life style.

基于生活方式和基因诊断的癌症风险评估——针对生活方式的行为。

• 批准号: 13670374
• 负责人: KATOH Takahiko
• 金额: $ 0.77万
• 依托单位: 宮崎医科大学
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670374/
• 关键词: Cytochrome P450; Sulfotransferase; N-acetyltransferase; Vitamin D receptor; Genetic polymorphism; Molecular epidemiology; Individual difference; urothelial cancer; 腎細胞癌; 胃癌; 前立腺癌

We studied the influence on differing individuals of drug metabolic enzymes (Cytochrome P450, Glutathione S-transferase (GST), phenol-sulfating phenol sulfotransferase (SAT), N-acetyltransferase (NAT)), and vitamin D receptor (VDR). Following are the results : 1) cancer-causing relevance ; 2) assessment of intervention study that feedback of genetic susceptibility to behavioral change.1) A case control study was carried out to examine the relationship between the genetic polymorphisms of seven genes, cigarette smoking and gastric, urothelial and prostate cancer. As a result, we found that the CYP2A6 deletion was associated with gastric adenocarcinoma. However, genetic polymorphisms of CYP2A6 and CYP2E1 were not associated with risk of urothelial cancer. NAT2 and ST1A3 genetic polymorphisms are heredity factors in the occurrence of urothelial cancer. CYP1A1 polymorphism and its combinations with GSTM1 may be associated with prostate cancer susceptibility. In addition, while investigating the relationship between prostate and renal cancer with VDR genetic polymorphism, we found that there were significant relationships between them respectively. To investigate the relationship between cancer and the quantity of smoking, we divided the research group by a genotype of NAT2. Then we analyzed the quantity of smoking and its relationship to urothelial carcinogenesis. Different patterns of odds ratio were observed in a genotype of NAT2, and the existence of a group that was different in sensitivity to environmental chemical exposure was suggested.2) Markers of genetic susceptibility to alcohol -related cancer could personalize harms of smoking and motivate cessation. We selected a workplace that used this intervention study. Fifty-Six percent of workers agreed to genetic feedback of alcohol related cancer gene respectively.

我们研究了药物代谢酶（细胞色素P450、谷胱甘肽S-转移酶（GST）、苯酚硫酸化苯酚磺基转移酶（SAT）、N-乙酰转移酶（NAT））和维生素D受体（VDR）对不同个体的影响。结果如下：1）致癌相关性; 2）遗传易感性反馈行为改变的干预研究评估。1）进行病例对照研究，探讨七个基因的遗传多态性、吸烟与胃癌、尿路上皮癌和前列腺癌之间的关系。因此，我们发现CYP 2A 6缺失与胃腺癌相关。然而，CYP 2A 6和CYP 2 E1的基因多态性与尿路上皮癌的风险无关。NAT 2和ST 1A 3基因多态性是尿路上皮癌发生的遗传因素。CYP 1A 1基因多态性及其与GSTM 1的联合可能与前列腺癌易感性相关。另外，在研究VDR基因多态性与前列腺癌和肾癌的关系时，发现两者之间存在显著的相关性。为了研究癌症与吸烟量之间的关系，我们将研究组按NAT 2基因型划分。分析吸烟量与尿路上皮癌发生的关系。在NAT 2基因型中观察到不同的优势比模式，并证实存在对环境化学暴露敏感性不同的群体。2）酒精相关癌症的遗传易感性标志物可以个性化吸烟的危害并激励戒烟。我们选择了一个使用这种干预研究的工作场所。分别有五十六%的工人同意酒精相关癌基因的遗传反馈。

项目成果

Hiromasa Tsukino: "Genetic polymorphisms of CYP2A6 and CYP2E1 with Tobacco smoking is not associated with risk of urothelial cancer"Environmental Health and Preventive Medicine. 3. 129-131 (2002)

Hiromasa Tsukino：“吸烟引起的 CYP2A6 和 CYP2E1 基因多态性与尿路上皮癌的风险无关”《环境健康与预防医学》。

Hiromasa Tsukino, Yoshiki Kuroda, Delai Qiu, Hiroyuki Nakao, Hirohisa Imai, Takahiko Katoh: "Effects of cytochrome P450 (CYC) 2A6 gene and CYP2E1 genotype on gastric adenocarcinoma"Int.J.Cancer. 100. 425-428 (2002)

Hiromasa Tsukino、Yoshiki Kuroda、Delai Qiu、Hiroyuki Nakao、Hirohisa Imai、Takahiko Katoh：“细胞色素 P450 (CYC) 2A6 基因和 CYP2E1 基因型对胃腺癌的影响”Int.J.Cancer。

Hiromasa Tsukino, Yoshiki Kuroda, Hiroyuki Nakao, Hirohisa Imai, Yukio Osada, Hisato Inatomi, Kyoko Kitagawa, Toshihiro Kawamoto, Takahiko Katoh: "Genetic polymorphisms of CYP2A6 and CYP2E1 with Tobacco smoking is not associated with risk of urothelial ca

Hiromasa Tsukino、Yoshiki Kuroda、Hiroyuki Nakao、Hirohisa Imai、Yukio Osada、Hisato Inatomi、Kyoko Kitakawa、Toshihiro Kawamoto、Takahiko Katoh：“吸烟引起的 CYP2A6 和 CYP2E1 基因多态性与尿路上皮癌风险无关

Takashi Hamasaki: "Signiflcance of Vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese"Urol Int. 68. 226-231 (2002)

Takashi Hamasaki：“维生素 D 受体基因多态性对日本人前列腺癌和良性前列腺增生的风险和疾病严重程度的意义”Urol Int.

Mihi Yang, Naoki Kunugita, Kyoko Kitagawa, Seung-Ho Kang, Brian Coles, Fred F Kadlubar, Takahiko Katoh, Koji Maysuno, Toshihiro Kawamoto: "Individual differences in urinary cotinine kevels in Japanese smokers : relation to genetic polymorphism of drug-met

Mihi Yang、Naoki Kunugita、Kyoko Kitakawa、Seung-Ho Kang、Brian Coles、Fred F Kadlubar、Takahiko Katoh、Koji Maysuno、Toshihiro Kawamoto：“日本吸烟者尿可替宁 kevel 的个体差异：与药物代谢物遗传多态性的关系