Application of genetic analysis towards occupational medicine -Development of efficient method for health promotion using genetic data base-

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In the occupational health, management of lifestyle diseases has become one of the most important issues. Lifestyle diseases occur as a result of interactions between external factors, including smoking, drinking, diet and exposure, and internal factors that genetic predisposed. We studied to examine whether the genetic diagnosis of susceptibility to disease is useful in supporting those who want to change their life style.Following ire the results: 1) assessment of intervention study that feedback of genetic susceptibility to behavioral change; 2) cancer-causing relevance gene.1) We selected a workplace that used this intervention study. The participants of this study were 420 male employees who wanted to know the re suit of their Aldehyde dehydrogenase (ALDH2) 2 genotype. We divided the 420 participants randomly into two groups. One is the "notified group", the members of which were notified of the result of the ALDH2 genotype earlier (n=139), and the other is the "non-notified group … More ", the members of which were notified of the results of the ALDH2 genotype at a later date (n=203). Drinking habits and laboratory data (GOT, GPT, γGTP) were obtained before and after notification of the ALDH2 genotype from regular medical health check-ups. Among those with genotype ALDH2^*1^*1, there was no significant change in drinking frequencies, nor was there any significant decline in liver function laboratory data in either of the groups before and after notification of the genotype. On the other hand, with regard to those who with genotype ALDH2^*1^*2, no significant changes in drinking frequencies and liver function laboratory data were evident in both groups before and after notification of the genotype. However, the weekly alcohol intake tended to increase in the non-notified group, whereas it tended to decrease in the notified group.2) A case control study was carried out to examine the relationship between the genetic polymorphisms of glutathione S-transferase (GST) Al genes, cigarette smoking and oral, urothelial and prostate cancer. As a result, we found that the CYP1A1 polymorphism was associated with risk of smokers with oral squamous and prostate cancers, and non-smokers with urothelial caner. Less