Application of genetic analysis towards occupational medicine -Development of efficient method for health promotion using genetic data base-

遗传分析在职业医学中的应用 -利用遗传数据库开发促进健康的有效方法-

• 批准号: 17590519
• 负责人: KATOH Takahiko
• 金额: $ 2.3万
• 依托单位: University of MIYAZAKI
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590519/
• 关键词: Genetic analysis; Drinking; ALDH2; Genetic polymorphism; Behavior Change

In the occupational health, management of lifestyle diseases has become one of the most important issues. Lifestyle diseases occur as a result of interactions between external factors, including smoking, drinking, diet and exposure, and internal factors that genetic predisposed. We studied to examine whether the genetic diagnosis of susceptibility to disease is useful in supporting those who want to change their life style.Following ire the results: 1) assessment of intervention study that feedback of genetic susceptibility to behavioral change; 2) cancer-causing relevance gene.1) We selected a workplace that used this intervention study. The participants of this study were 420 male employees who wanted to know the re suit of their Aldehyde dehydrogenase (ALDH2) 2 genotype. We divided the 420 participants randomly into two groups. One is the "notified group", the members of which were notified of the result of the ALDH2 genotype earlier (n=139), and the other is the "non-notified group … More ", the members of which were notified of the results of the ALDH2 genotype at a later date (n=203). Drinking habits and laboratory data (GOT, GPT, γGTP) were obtained before and after notification of the ALDH2 genotype from regular medical health check-ups. Among those with genotype ALDH2^*1^*1, there was no significant change in drinking frequencies, nor was there any significant decline in liver function laboratory data in either of the groups before and after notification of the genotype. On the other hand, with regard to those who with genotype ALDH2^*1^*2, no significant changes in drinking frequencies and liver function laboratory data were evident in both groups before and after notification of the genotype. However, the weekly alcohol intake tended to increase in the non-notified group, whereas it tended to decrease in the notified group.2) A case control study was carried out to examine the relationship between the genetic polymorphisms of glutathione S-transferase (GST) Al genes, cigarette smoking and oral, urothelial and prostate cancer. As a result, we found that the CYP1A1 polymorphism was associated with risk of smokers with oral squamous and prostate cancers, and non-smokers with urothelial caner. Less

在职业卫生中，生活方式疾病的管理已成为最重要的问题之一。生活方式疾病的发生是外部因素（包括吸烟、饮酒、饮食和暴露）与遗传易感性的内部因素相互作用的结果。我们研究了对疾病易感性的遗传诊断是否对那些想要改变生活方式的人有用。研究结果如下：1)遗传易感性对行为改变反馈的干预研究评估；2)致癌相关基因。1)我们选择了一个使用此干预研究的工作场所。本研究的参与者是420名男性员工，他们想知道他们的醛脱氢酶（ALDH2） 2基因型的结果。我们将420名参与者随机分为两组。一组为“通报组”，通报ALDH2基因型结果较早（n=139）；另一组为“未通报组…More”，通报ALDH2基因型结果较晚（n=203）。通过定期体检获得ALDH2基因型通报前后的饮酒习惯和实验室数据（GOT、GPT、γGTP）。在ALDH2^*1^*1基因型患者中，饮酒频率无显著变化，两组患者在告知基因型前后肝功能实验室数据均无显著下降。另一方面，对于ALDH2^*1^*2基因型患者，两组在告知基因型前后，饮酒频率和肝功能实验室数据均无明显变化。然而，每周的酒精摄入量在未被告知的那一组有增加的趋势，而在被告知的那一组有减少的趋势。2)通过病例对照研究，探讨谷胱甘肽s -转移酶（GST） Al基因遗传多态性与吸烟与口腔癌、尿路上皮癌和前列腺癌的关系。因此，我们发现CYP1A1多态性与吸烟者患口腔鳞状癌和前列腺癌以及不吸烟者患尿路上皮癌的风险相关。少

项目成果

Glutathione S-transferase M1 (GSTM1)およびAldehyde dehydrogenase 2 (ALDH2)遺伝子多型の遺伝子診断に対する意識調査-行動変容ツールとしての遺伝子診断の可能性について-

谷胱甘肽S-转移酶M1（GSTM1）和醛脱氢酶2（ALDH2）基因多态性基因诊断认知度调查 - 关于基因诊断作为行为改变工具的可能性 -

• 发表时间: 2005
• 期刊: 産業衛生学雑誌 47/5
• 作者: 小宮 康裕;中尾 裕之;黒田 嘉紀;有薗 克晋;中原 愛;加藤 貴彦
• 通讯作者: 加藤 貴彦

Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population

• DOI: 10.1007/s00432-004-0634-z
• 发表时间: 2005-04-01
• 期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
• 影响因子: 3.6
• 作者: Komiya, Y;Tsukino, H;Katoh, T
• 通讯作者: Katoh, T

Human glutathione S-transferase Al, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population.

日本人群中人谷胱甘肽 S-转移酶 A1、T1、M1 和 P1 多态性和前列腺癌易感性。

• 发表时间: 2005
• 期刊: J. Cancer Res. Clin. Oncol. 131
• 作者: Komiya Y.;Tsukino H.;Nakao H.;Kuroda Y.;Imai H.;Katoh T.
• 通讯作者: Katoh T.

Human glutathione S-transferase Al polymorphism and susceptibility to urothelial cancer in the Japanese population

日本人群人谷胱甘肽 S-转移酶 Al 多态性与尿路上皮癌易感性

• 发表时间: 2005
• 期刊: Cancer Letters Vol.221
• 作者: Kawaguchi;A.;柳川 尭;内田 英二;Teruo Itoh;De-Lai Qiu;Hiroyuki Komatsu;Yasuhiro Komiya;Masaki Tsuchiya;Yasuhiro Komiya
• 通讯作者: Yasuhiro Komiya

Human glutathione S-transferase A1 polymorphisms and susceptibility to oral squamous cell carcinoma in Japanese.

日本人谷胱甘肽 S-转移酶 A1 多态性与口腔鳞状细胞癌易感性。

• 发表时间: 2005
• 期刊: Environ. Health Prev. Med. 10
• 作者: Komiya Y;Kuroda Y.;Nakao H.;Arizono K.;Nakahara A.;Katoh T.
• 通讯作者: Katoh T.