Association between periodontal treatment and metabolic syndrome

探讨牙周治疗对慢性牙周炎(CP)患者血清瘦素等细胞因子水平的影响。采集33例CP患者(22例非吸烟者，11例吸烟者)和18例健康人的血清标本。测定非手术牙周治疗前后血清瘦素、脂联素、肿瘤坏死因子-A、白介素6、C反应蛋白水平。牙周治疗能有效降低血清瘦素、IL-6和CRP水平。提示瘦素、IL-6、CRP可能是代谢综合征与牙周炎之间的中介因子。

This study investigated the effects of periodontal treatment on the serum levels of leptin and other cytokines in patients with chronic periodontitis (CP). Serum samples were taken from 33 CP patients (22 non-smokers, 11 smokers) and 18 healthy subjects. The serum leptin, adiponectin, tumor necrosis factor (TNF)-A, interleukin (IL)-6, and C-reactive protein (CRP) levels were measured before and after non-surgical periodontal treatment. Periodontal treatment is effective in reducing serum leptin, IL-6, and CRP levels. The results suggest that leptin, IL-6, and CRP could be mediating factors that connect metabolic syndrome and periodontitis.