Association between metabolic syndrome and periodontitis through adipocytokine in GCF

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Eleven patients with generalized chronic periodontitis were enrolled. Forty biomarkers in GCF were examined using a multiplex bead immunoassay. Porphyromonas gingivalis (P. gingivalis) from the diseased sites was quantified by real-time polymerase chain reaction. Interleukin (IL)-1beta and interferon-inducible protein (IP)-10 levels were significantly higher in BOP-positive diseased sites than BOP-negative diseased sites after adjustment for multiple comparisons. In addition, the levels of IL-1beta in GCF were found to be strongly correlated with the P. gingivalis ratio. IL-1beta levels in GCF correlate with the presence of P. gingivalis in subgingival plaque. Multiplex bead assays can be useful in GCF studies. These findings can help in identifying new diagnostic methods in the diagnosis of periodontal disease.