The role of lipid-mediated intercellular communications in neuronal circuit development and regeneration
The role of lipid-mediated intercellular communications in neuronal circuit development and regeneration
批准号:
21200009
负责人:
KAMIGUCHI Hiroyuki
金额:
$19.14万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Axon growth along the correct path is necessary for neuronal circuit formation. We have discovered the axon-guiding lipid molecule Lysophosphatidylglucoside (LysoPtdGlc), identified its receptor and downstream signaling pathway, and elucidateid its functional significance in the spinal sensory axon tract formation. In contrast to previous studies on the role of proteins as axon guidance cues, thei project has demonstrated the importance of lipid-mediateid axon guidance in neuronal circuit formation
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Lipid-mediated axon guidance in the developing spinal cord.
发育中的脊髓中脂质介导的轴突引导。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Z. A. Khan, M. Iwaoka, T. Wirth, H.Sagawa, Keiji Tanaka, Kamiguchi H.]
通讯作者:
Kamiguchi H.
Scond messengers and membrane trafficking direct and organize growth cone steering
第二信使和膜运输指导和组织生长锥转向
DOI:
--
发表时间:
2011
期刊:
Nat Rev Neurosci
影响因子:
34.7
作者:
[Tojima T, Hines JH, Henley JR, Kamiguchi H]
通讯作者:
Kamiguchi H
Lipid-mediated axon guidance in the developing spinal cord
发育中的脊髓中脂质介导的轴突引导
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[生駒佳祐, 久本秀明, 川村邦男, Hisashi Shimizu, 田中啓二, Adam T.Guy]
通讯作者:
Adam T.Guy
DOI:
10.1016/j.neuron.2010.04.007
发表时间:
2010-05-13
期刊:
NEURON
影响因子:
16.2
作者:
[Tojima, Takuro, Itofusa, Rurika, Kamiguchi, Hiroyuki]
通讯作者:
Kamiguchi, Hiroyuki
Asymmetric endocytosis across the growth cone that controls axon guidance
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批准号:21500361
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:KAMIGUCHI Hiroyuki
-
依托单位:
Mechanisms of repulsive axon guidance: Elucidation of asymmetric driving machinery in the growth cone
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批准号:19500335
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2007
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负责人:KAMIGUCHI Hiroyuki
-
依托单位:
Regulation of axon growth and guidance by lipid rafts
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批准号:16500210
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2004
-
负责人:KAMIGUCHI Hiroyuki
-
依托单位:
Molecular Mechanisms of L1-dependnet axon growth (intracellular L2-trafficking and signaling pathways)
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批准号:13680857
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2001
-
负责人:KAMIGUCHI Hiroyuki
-
依托单位:
海外基金