权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Physiological characteristics of the striatal striosome circuits

纹状体纹状体回路的生理特征

基本信息

批准号：
21200015
负责人：
AOSAKI Toshihiko
金额：
$ 19.8万
依托单位：
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Output neurons of the striosome compartment of the striatum are one of the important components the neural pathway responsible for development and execution of stereotyped behaviors. They are exclusively equipped with μ-opioid receptors in the striatum. We found that prior blockade of protein kinase C (PKC) augments the suppressive effect of μ-opioid receptors (MORs) on the GABAergic inhibitory postsynaptic current (IPSC) in the MOR-rich striosomes of the striatum. Interestingly, Striatal medium spiny neurons have muscarinic acetylcholine receptor subtypes M1 and M4, among which M1 activates the phosphoinositide signaling pathway yielding PKC. We examined whether acetylcholine regulates MOR’s effects on presynaptic IPSC by binding to the M1 receptor, and found that IPSC suppression by the MOR agonist DAMGO was significantly augmented and prolonged by the PKC inhibitor chelerythrine and attenuated by the PKC activator PDBu. These results suggest that PKC activity modulates MOR’s effect via muscarinic receptors in the striosomes.

纹状体纹状体室的输出神经元是刻板行为发生和执行的神经通路的重要组成部分之一。它们在纹状体中专门配备了μ-阿片受体。我们发现，预先阻断蛋白激酶C （PKC）可增强μ-阿片受体（MORs）对纹状体富含MORs的纹状体中gaba能抑制性突触后电流（IPSC）的抑制作用。有趣的是，纹状体中棘神经元具有毒蕈碱乙酰胆碱受体M1和M4亚型，其中M1激活产生PKC的磷酸肌苷信号通路。我们研究了乙酰胆碱是否通过与M1受体结合来调节MOR对突触前IPSC的影响，发现MOR激动剂DAMGO对IPSC的抑制作用被PKC抑制剂chelerythrine显著增强和延长，而被PKC激活剂PDBu减弱。这些结果表明，PKC活性通过纹状体中的毒蕈碱受体调节MOR的作用。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Activin Bi-directionally Controls the Fate of Fear Memory.

激活素双向控制恐惧记忆的命运。

DOI：
发表时间：
2010
期刊：
Learning and Memory
影响因子：
2
作者：
Ageta;H.;Ikegami;S.;Miura;M.;Masuda;M.;Migishima;R.;Hino;T.;Takashima;N.;Murayama;A.;Sugino;H.;Setou;M.;Kida;S.;Yokoyama;M.;Yoshihisa Hasegawa;Y.;Tsuchida;K.;Aosaki;T.;Inokuchi;K.
通讯作者：
K.

Roles of cholinergic interneurons in inter-compartmental communication and synaptic plasticity in the striatum.

胆碱能中间神经元在纹状体间通讯和突触可塑性中的作用。