Development of the anti-tumor DDS based on novel tumor-homing peptides

我们开发了新的肿瘤谱系归巢CPPs，根据其肿瘤谱系，CPPs对癌细胞具有高度渗透性。利用mRNA展示技术构建随机肽库，分离不同于TAT、pAnt等传统CPPs的新型氨基酸序列编码的CPPs。筛选了40多个CPPs，其中10个显示出独特的反应，可以在肿瘤起源后有效地结合到肿瘤细胞中。这些肿瘤谱系归巢CPPs在体内和体外有效地结合到靶细胞中，在基于肽的非侵入性医疗技术中很有用，如抗癌治疗和成像。

We developed novel tumor linegae-homing CPPs that are highly permeable to cancer cells according to their tumor linages. Random peptide library constructed by mRNA display technology was employed for isolating the CPPs encoded by novel aminoacid sequences which differ from conventional CPPs such as TAT,pAnt. Screening of over 40 CPPs of these,10 of them showed unique response that were efficiently incorporated to tumor cells following their tumor origins. These tumor linage-homing CPPs were efficiently incorporated to target cells in vivo and in vitro and are useful in peptide-based non-invasive medical technologies such as anti-cancer therapeutics and imaging.