Development of the anti-tumor DDS based on novel tumor-homing peptides

基于新型肿瘤归巢肽的抗肿瘤DDS的开发

• 批准号: 21200078
• 负责人: KONDO Eisaku
• 金额: $ 19.8万
• 依托单位: 愛知県がんセンター研究所 (2011)Aichi Cancer Center Research Institute (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21200078/
• 关键词: 分子腫瘍学; ドラッグデリバリー; 細胞選択的透過性ペプチド; がん細胞; 分子標的

We developed novel tumor linegae-homing CPPs that are highly permeable to cancer cells according to their tumor linages. Random peptide library constructed by mRNA display technology was employed for isolating the CPPs encoded by novel aminoacid sequences which differ from conventional CPPs such as TAT,pAnt. Screening of over 40 CPPs of these,10 of them showed unique response that were efficiently incorporated to tumor cells following their tumor origins. These tumor linage-homing CPPs were efficiently incorporated to target cells in vivo and in vitro and are useful in peptide-based non-invasive medical technologies such as anti-cancer therapeutics and imaging.

我们开发了新的肿瘤谱系归巢CPP，其根据其肿瘤谱系对癌细胞具有高度渗透性。利用mRNA展示技术构建的随机肽库，筛选出与达特、pAnt等传统CPP不同的新氨基酸序列编码的CPP。筛选其中超过40种CPP，其中10种显示出独特的反应，这些反应在肿瘤起源后有效地掺入肿瘤细胞。这些肿瘤谱系归巢CPP在体内和体外有效地掺入靶细胞，并且可用于基于肽的非侵入性医疗技术，如抗癌治疗和成像。

项目成果

Tumour lineage-homing cell-penetrating peptides for peptide-based anti-cancer molecular delivery systems. (※ correspondence ; Kondo E and Matsushita M)

用于基于肽的抗癌分子递送系统的肿瘤谱系归巢细胞穿透肽（※对应；Kondo E 和 Matsushita M）。

• 发表时间: 2012
• 期刊: Nature Communications
• 影响因子: 16.6
• 作者: Kondo E;Saito K;Tashiro Y;Kamide K;Uno S;Furuya T;Mashita M;Nakajima K;Tsumuraya T;Kobayashi N;Nishibori M;Tanimoto M;Matsushita M
• 通讯作者: Matsushita M

ヒト各種悪性腫瘍細胞におけるCXADR 分子の発現の特徴とその生物学的役割についての解析

CXADR分子在人多种恶性肿瘤细胞中的表达特征及其生物学作用分析

• 发表时间: 2010
• 作者: 松井誠;中西速夫;近藤英作
• 通讯作者: 近藤英作

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