Development of the anti-tumor DDS based on novel tumor-homing peptides

我们开发了新型的肿瘤线粒归宿CPP，根据肿瘤细胞的线条，这种CPP对癌细胞具有高度的渗透性。利用mRNA展示技术构建的随机多肽文库用于分离不同于TAT、PANT等新的氨基酸序列所编码的CPPs。对其中的40多个CPP进行了筛选，其中10个显示出独特的反应，这些反应在肿瘤起源后有效地整合到肿瘤细胞上。这些肿瘤线形归巢的CPP在体内和体外都能有效地整合到靶细胞上，在抗癌治疗和成像等基于多肽的非侵入性医学技术中是有用的。

We developed novel tumor linegae-homing CPPs that are highly permeable to cancer cells according to their tumor linages. Random peptide library constructed by mRNA display technology was employed for isolating the CPPs encoded by novel aminoacid sequences which differ from conventional CPPs such as TAT,pAnt. Screening of over 40 CPPs of these,10 of them showed unique response that were efficiently incorporated to tumor cells following their tumor origins. These tumor linage-homing CPPs were efficiently incorporated to target cells in vivo and in vitro and are useful in peptide-based non-invasive medical technologies such as anti-cancer therapeutics and imaging.